The Effect of Low-Level Laser in Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial
The Effect of Low-Level Laser in Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial
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DOI：
10.1089/pho.2008.2297
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发表时间：
2009-08-01
影响因子：
--
通讯作者：
Galfi, Marta
中科院分区：
文献类型：
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作者：
Hegedus, Bela;Viharos, Laszlo;Galfi, Marta
简介：低强度激光疗法（LLLT）被认为具有镇痛作用以及对微循环的生物调节作用。本研究旨在检验 LLLT 的镇痛效果以及通过热成像技术测量膝骨关节炎 (KOA) 患者可能发生的微循环变化。材料和方法：轻度或中度 KOA 患者被随机分配接受 LLLT 或安慰剂 LLLT。治疗每周两次，持续 4 周，使用二极管激光（波长 830 nm，连续波，功率 50mW）以 6 J/点的剂量接触皮肤。安慰剂对照组使用外观相同的无效探针（功率0.5mW）进行治疗。检查前以及治疗结束后立即、2周和2个月进行热成像（AGA红外热像仪双侧对比热成像）；测量关节屈曲、周长和压力敏感性；并记录视觉模拟量表。结果：在积极 LLLT 治疗组中，疼痛明显改善（治疗前 [BT]：5.75；治疗后 2 个月：1.18）；周长（BT：40.45；AT：39.86）；压力灵敏度（BT：2.33；AT：0.77）；和屈曲（BT：105.83；AT：122.94）。在安慰剂组中，关节屈曲和疼痛的变化并不显着。热成像测量显示温度至少升高了 0.5 摄氏度，因此与初始值相比，循环有所改善。在安慰剂组中，这些变化没有发生。结论：我们的结果表明 LLLT 可以减轻 KOA 的疼痛并改善照射区域的微循环。
Introduction: Low-level laser therapy (LLLT) is thought to have an analgesic effect as well as a biomodulatory effect on microcirculation. This study was designed to examine the pain-relieving effect of LLLT and possible microcirculatory changes measured by thermography in patients with knee osteoarthritis (KOA). Materials and Methods: Patients with mild or moderate KOA were randomized to receive either LLLT or placebo LLLT. Treatments were delivered twice a week over a period of 4wk with a diode laser (wavelength 830 nm, continuous wave, power 50mW) in skin contact at a dose of 6 J/point. The placebo control group was treated with an ineffective probe (power 0.5mW) of the same appearance. Before examinations and immediately, 2 wk, and 2 mo after completing the therapy, thermography was performed (bilateral comparative thermograph by AGA infrared camera); joint flexion, circumference, and pressure sensitivity were measured; and the visual analogue scale was recorded. Results: In the group treated with active LLLT, a significant improvement was found in pain (before treatment [BT]: 5.75; 2 mo after treatment : 1.18); circumference (BT: 40.45; AT: 39.86); pressure sensitivity (BT: 2.33; AT: 0.77); and flexion (BT: 105.83; AT: 122.94). In the placebo group, changes in joint flexion and pain were not significant. Thermographic measurements showed at least a 0.5 degrees C increase in temperature-and thus an improvement in circulation compared to the initial values. In the placebo group, these changes did not occur. Conclusion: Our results show that LLLT reduces pain in KOA and improves microcirculation in the irradiated area.