Autoantibodies in Alzheimer's disease: potential biomarkers, pathogenic roles, and therapeutic implications.
Autoantibodies in Alzheimer's disease: potential biomarkers, pathogenic roles, and therapeutic implications.
复制标题
DOI：
10.7555/jbr.30.20150131
复制
发表时间：
2016-09
影响因子：
2.3
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Wu J;Li L
阿尔茨海默病（AD）是一种在老年人中普遍存在的神经退行性疾病。阿尔茨海默病的病因尚未完全确定，目前还没有治愈这种毁灭性疾病的方法。令人信服的证据表明，免疫系统在阿尔茨海默病的病理生理中起着至关重要的作用。抗多种分子的自身抗体与AD有关。然而，这些自身抗体在阿尔茨海默病中的作用尚不清楚。本文试图总结这些自身抗体的最新发现，并探讨它们作为AD诊断/预后生物标志物的潜力，它们在AD发病机制中的作用，以及它们在开发有效的AD免疫疗法中的意义。
Alzheimer’s disease (AD) is a prevalent and debilitating neurodegenerative disorder in the elderly. The etiology of AD has not been fully defined and currently there is no cure for this devastating disease. Compelling evidence suggests that the immune system plays a critical role in the pathophysiology of AD. Autoantibodies against a variety of molecules have been associated with AD. The roles of these autoantibodies in AD, however, are not well understood. This review attempts to summarize recent findings on these autoantibodies and explore their potential as diagnostic/ prognostic biomarkers for AD, their roles in the pathogenesis of AD, and their implications in the development of effective immunotherapies for AD.