The role of interleukin-1 in disease.
The role of interleukin-1 in disease.
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DOI：
10.1056/nejm199301143280207
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发表时间：
1993-01
期刊：
影响因子：
--
通讯作者：
C. Dinarello;S. Wolff
中科院分区：
文献类型：
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作者：
C. Dinarello;S. Wolff
白细胞介素-1家族由三种结构相关的多肽组成。前两种是白细胞介素-1 α和白细胞介素-1 β，它们都具有广泛的有益和有害的生物学作用，第三种是白细胞介素-1受体拮抗剂，它抑制白细胞介素-1的活性。在两种形式的白细胞介素-1（α和β）的特性中，能够引起发热、睡眠、厌食和低血压。白细胞介素-1刺激垂体激素的释放，增加胶原酶的合成，导致软骨的破坏，并刺激胡萝卜素的产生，导致痛阈降低。白细胞介素-1也是。. .
The interleukin-1 family consists of three structurally related polypeptides. The first two are interleukin-1α and interleukin-1β, each of which has a broad spectrum of both beneficial and harmful biologic actions, and the third is interleukin-1-receptor antagonist, which inhibits the activities of interleukin-1. Among the properties of the two forms of interleukin-1 (α and β) is the ability to induce fever, sleep, anorexia, and hypotension. Interleukin-1 stimulates the release of pituitary hormones, increases the synthesis of collagenases, resulting in the destruction of cartilage, and stimulates the production of prostaglandins, leading to a decrease in the pain threshold. Interleukin-1 has also been . . .