Newly Identified Roles of PML in Stem Cell Biology.
Newly Identified Roles of PML in Stem Cell Biology.
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DOI：
10.3389/fonc.2013.00050
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发表时间：
2013
影响因子：
4.7
通讯作者：
Ito K
中科院分区：
文献类型：
--
作者：
Ito K;Ito K
长期以来，人们一直认为肿瘤抑制因子早幼粒细胞白血病（PML）是被称为PML核小体的核亚结构的核心成分，在急性早幼粒细胞白血病（APL）中起着关键作用，因为它首先在该疾病典型的t（15;17）易位的断点上被克隆。然而，过去十年的研究已经从根本上改变了我们对这种肿瘤抑制因子是如何被调节的，它是如何被靶向治疗的，以及它是如何在许多组织系统中起作用的。例如，最近一项值得注意的研究表明，PML调节脂肪酸代谢的激活，这种代谢重编程通过控制干细胞命运决定在癌症生物学和干细胞生物学中发挥重要作用。这些发现引发了对PML作为一个关键的“变阻器”负责微调组织稳态的令人兴奋的新研究，从而在癌症和干细胞生物学的交叉点上创造了一个具有重要治疗意义的新研究领域。
It has long been believed that the tumor suppressor promyelocytic leukemia (PML), the core component of the nuclear substructures known as the PML-nuclear bodies, plays a key part in acute PML (APL), as it is first cloned at the breakpoint of the t(15;17) translocation typical of that disease. Research over the past decade, however, has radically changed our view of how this tumor suppressor is regulated, how it can be therapeutically targeted, and how it functions in a number of tissue systems. One noteworthy recent study, for instance, revealed that PML regulates the activation of fatty acid metabolism, and that this metabolic reprograming plays an essential role in cancer biology and stem cell biology through the control it exerts over stem cell fate decisions. These findings sparked exciting new investigations of PML as a critical “rheostat” responsible for fine-tuning tissue homeostasis, and thus created at the intersection of cancer and stem cell biology a new field of study with important therapeutic implications.