The world epidemic of sleep disorders is linked to vitamin D deficiency
The world epidemic of sleep disorders is linked to vitamin D deficiency
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DOI：
10.1016/j.mehy.2012.03.031
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发表时间：
2012-08-01
影响因子：
4.7
通讯作者：
Stumpf, W. E.
中科院分区：
文献类型：
--
作者：
Gominak, S. C.;Stumpf, W. E.
通过观察维生素D补充剂对睡眠的改善，在1500例有神经系统疾病的患者中进行了为期2年的维生素D补充剂非对照试验，这些患者也有睡眠异常的证据。大多数患者的神经症状和睡眠有所改善，但仅通过维持60-80 ng/ml的25（OH）维生素D3血液水平的狭窄范围。与睡眠-觉醒调节相关的大脑区域和间脑和几个脑干核团中的维生素D靶神经元的比较表明维生素D对睡眠的直接中枢作用。我们提出的假设是，睡眠障碍已经成为流行病，因为普遍缺乏维生素D。维生素D的治疗效果与解剖功能的对应关系，值得进一步研究和考虑在睡眠障碍的病因学和治疗。(C)2012爱思唯尔有限公司保留所有权利。
An observation of sleep improvement with vitamin D supplementation led to a 2 year uncontrolled trial of vitamin D supplementation in 1500 patients with neurologic complaints who also had evidence of abnormal sleep. Most patients had improvement in neurologic symptoms and sleep but only through maintaining a narrow range of 25(OH) vitamin D3 blood levels of 60-80 ng/ml. Comparisons of brain regions associated with sleep-wake regulation and vitamin D target neurons in the diencephalon and several brainstem nuclei suggest direct central effects of vitamin D on sleep. We propose the hypothesis that sleep disorders have become epidemic because of widespread vitamin D deficiency. The therapeutic effects together with the anatomic-functional correspondence warrant further investigation and consideration of vitamin D in the etiology and therapy of sleep disorders. (C) 2012 Elsevier Ltd. All rights reserved.