Enhanced parasympathetic tone shortens atrial refractoriness in man.
Enhanced parasympathetic tone shortens atrial refractoriness in man.
复制标题
增强的副交感神经张力可缩短人类心房不应期。
DOI：
10.1016/s0002-9149(83)80018-6
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
D. Zipes
中科院分区：
文献类型：
--
作者：
E. Prystowsky;G. Naccarelli;Warren M. Jackman;R. Rinkenberger;J. Heger;D. Zipes
The purpose of this study was to determine the effects of enhanced vagal tone on human right atrial refractoriness in 12 patients. A specially built neck collar connected to a vacuum source was placed around the patient's neck and enhanced vagal tone was produced during neck suction using intracollar negative pressures of 50 to 60 mm Hg. Refractory periods were determined with a catheter electrode positioned in the high right atrium near the sinus node. Induced neck suction increased the spontaneous sinus cycle length from 837 ± 96 to 1,136 ± 273 ms (p <0.001) and shortened the atrial effective refractory period from 241 ± 24 to 230 ± 20 ms (p <0.01) and the atrial functional refractory period from 272 ± 32 to 262 ± 29 ms (p <0.01). In 2 of 2 patients, collar-induced decreases in atrial refractoriness and increases in spontaneous cycle length were prevented after atropine (0.03 mg/kg) was given intravenously. It is concluded that enhanced vagal tone mediated through muscarinic receptors shortens atrial refractory periods in man.
