Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease
Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease
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DOI：
10.1016/j.dld.2009.08.002
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发表时间：
2010-07-01
影响因子：
4.5
通讯作者：
Lee, Hyo-Suk
中科院分区：
文献类型：
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作者：
Lee, Jeong-Hoon;Kim, Donghee;Lee, Hyo-Suk
背景/目的：为了优化非酒精性脂肪性肝病（NAFLD）的管理，需要一种简单的筛查工具。在这项研究中，我们的目的是设计一个简单的指数NAFLD。研究：进行了一项横断面研究，10,724名健康检查对象（5362例NAFLD与年龄和性别匹配的对照组）。结果：多因素分析显示，高血清谷丙转氨酶（ALT）/谷草转氨酶（AST）比值、高体重指数（BMI）和糖尿病是NAFLD的独立危险因素（均P
Background/Aims: To optimize management of nonalcoholic fatty liver disease (NAFLD), a simple screening tool is necessary. In this study, we aimed to devise a simple index of NAFLD.Study: A cross-sectional study with 10,724 health check-up subjects (5362 cases with NAFLD versus age- and sex-matched controls) was conducted. Study subjects were randomly assigned to a derivation cohort or a validation cohort.Results: Multivariate analysis indicated that high serum alanine aminotransferase (ALT) to serum aspartate aminotransferase (AST) ratio, high body mass index (BMI), and diabetes mellitus were independent risk factors of NAFLD (all P