Mitochondrion-Specific Live-Cell Bioprobe Operated in a Fluorescence Turn-On Manner and a Well-Designed Photoactivatable Mechanism
Mitochondrion-Specific Live-Cell Bioprobe Operated in a Fluorescence Turn-On Manner and a Well-Designed Photoactivatable Mechanism
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DOI：
10.1002/adma.201503751
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发表时间：
2015-11-25
影响因子：
29.4
通讯作者：
Tang, Ben Zhong
中科院分区：
文献类型：
--
作者：
Gu, Xinggui;Zhao, Engui;Tang, Ben Zhong
一种新的线粒体特异性活细胞荧光开启光激活生物探针，命名为o-TPP3M，设计并制备了一种新的基于扭曲分子内电荷转移效应、分子内旋转限制和光环脱氢的光激活机制。该生物探针具有独特的光激活行为，大的信号与背景比，对活细胞无细胞毒性，为各种生物研究提供了有希望的候选物。
A novel mitochondrion-specific live-cell fluorescence turn-on photoactivatable bioprobe, named o-TPP3M, is designed and readily prepared, operating in a new photoactivatable mechanism based on a twisted intramolecular charge-transfer effect, the restriction of intramolecular rotations, and photocyclodehydrogenation. This bioprobe exhibits unique photoactivation behavior, a large signal-to-background ratio, and no cytotoxicity to living cells, providing a promising candidate for varied bioresearch.