Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Desulfonylation and C(sp2)-N Bond Formation of Conjugated Tosyl Amides
Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Desulfonylation and C(sp2)-N Bond Formation of Conjugated Tosyl Amides
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DOI：
10.1021/ja403954g
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发表时间：
2013-10-02
影响因子：
15
通讯作者：
Nevado, Cristina
中科院分区：
文献类型：
--
作者：
Kong, Wangqing;Casimiro, Maria;Nevado, Cristina
以共轭对甲苯磺酰胺为起始原料，研究了铜催化的一锅法三氟甲基化/芳基迁移/脱磺基化和C(sp(2))-N键形成反应。该反应以区域选择性的方式提供了带有四元立体中心或三氟甲基氧吲哚的α-芳基-β-三氟甲基酰胺。
A novel copper-catalyzed one-pot trifluoromethylation/aryl migration/desulfonylation and C(sp(2))-N bond formation with conjugated tosyl amides as starting materials is presented here. The reaction affords alpha-aryl-beta-trifluoromethyl amides bearing a quaternary stereocenter or trifluoromethylated oxindoles in a regioselective manner.