Trafficking of Adhesion and Growth Factor Receptors and Their Effector Kinases.
Trafficking of Adhesion and Growth Factor Receptors and Their Effector Kinases.
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DOI：
10.1146/annurev-cellbio-100617-062559
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发表时间：
2018-10
影响因子：
11.3
通讯作者：
C. Schoenherr;M. Frame;Adam Byron
中科院分区：
文献类型：
--
作者：
C. Schoenherr;M. Frame;Adam Byron
细胞粘附到微环境中的大分子对于组织的发育和维持是必不可少的，并且其失调可导致一系列疾病状态，包括炎症、纤维化和癌症。介导细胞粘附的生物力学和生物化学机制依赖于一系列效应蛋白的信号传导，包括激酶和相关的支架蛋白。这些的细胞内运输必须在空间和时间上受到严格控制，以实现有效的细胞粘附和微环境传感，并将细胞粘附与其他细胞过程（如基因转录，蛋白质降解和细胞分裂）整合并将其分隔开。粘附受体和信号蛋白从质膜到未预料到的亚细胞区域的传递揭示了新的生物学功能。在这里，我们回顾了粘附和生长因子受体以及细胞内激酶伴侣的预期和意外的运输以及活性位点，因为我们开始了解它们空间调节的复杂性和多样性。
Cell adhesion to macromolecules in the microenvironment is essential for the development and maintenance of tissues, and its dysregulation can lead to a range of disease states, including inflammation, fibrosis, and cancer. The biomechanical and biochemical mechanisms that mediate cell adhesion rely on signaling by a range of effector proteins, including kinases and associated scaffolding proteins. The intracellular trafficking of these must be tightly controlled in space and time to enable effective cell adhesion and microenvironmental sensing and to integrate cell adhesion with, and compartmentalize it from, other cellular processes, such as gene transcription, protein degradation, and cell division. Delivery of adhesion receptors and signaling proteins from the plasma membrane to unanticipated subcellular locales is revealing novel biological functions. Here, we review the expected and unexpected trafficking, and sites of activity, of adhesion and growth factor receptors and intracellular kinase partners as we begin to appreciate the complexity and diversity of their spatial regulation.