Smooth Muscle Tumors of the Vulva
Smooth Muscle Tumors of the Vulva
复制标题
外阴平滑肌肿瘤
作者：
F. Tavassoli;H. Norris
对32例外阴平滑肌肿瘤的临床和病理特征进行了研究，以确定与临床行为最相关的病理特征，并确定平滑肌瘤与平滑肌肉瘤的鉴别标准。随访时间从16个月到20年不等，中位数为9年。没有一个肿瘤转移。复发的4例肿瘤中，2例边缘浸润的肿瘤在1年内复发，其中1例在10个高倍视野（HPF）中有5个以上核分裂像的肿瘤在2年内复发5次。7例患者在妊娠期间发现了肿瘤，这些肿瘤的特征是广泛的粘液样变化，但妊娠期间发生的肿瘤均未显示出显著的细胞增殖或有丝分裂活性。建议局部切除作为初始治疗，也可用于复发。
The clinical and pathologic features of 32 smooth muscle tumors of the vulva were studied to determine the pathologic characteristics that best relate to the clinical behavior and to define criteria for separating leiomyomas from leiomyosarcomas. The length of follow-up ranged from 16 months to 20 years, with a median of 9 years. None of the tumors metastasized. Of the 4 neoplasms that recurred, the 2 with infiltrating margins recurred within 1 year and of these 2, the one with more than 5 mitotic figures in 10 high-power fields (HPF) recurred 5 times within a 2-year period. Neoplasms were discovered during pregnancy in 7 patients; these were characterized by extensive myxoid change, but none of the tumors that occurred during pregnancy showed significant cellular atypism or mitotic activity. Local excision is recommended as initial therapy and also for recurrences.