Nonsteroidal anti-inflammatory drug use and the risk of melanoma: a meta-analysis
Nonsteroidal anti-inflammatory drug use and the risk of melanoma: a meta-analysis
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非甾体抗炎药的使用和黑色素瘤的风险：荟萃分析
DOI：
10.1097/cej.0b013e328360f479
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发表时间：
2014-01
影响因子：
2.4
通讯作者：
Deng, Yanhong
中科院分区：
文献类型：
--
作者：
Hu, Huabin;Xie, Yangchun;Yang, Guorong;Jian, Chengzhu;Deng, Yanhong
包括阿司匹林在内的非甾体抗炎药（NSAID）已成为黑色素瘤的潜在化学预防剂。然而，关于非甾体抗炎药是否可以降低黑色素瘤的风险，临床研究提供了相互矛盾的结果。我们的目的是通过对同行评审文献中发表的有关该主题的研究进行详细的荟萃分析来评估这种关联。通过搜索截至 2012 年 7 月的 PubMed、EMBASE 和 Web of Science 电子数据库确定了相关研究。还对检索到的文章的参考文献列表进行了审查。基于异质性分析，使用固定效应或随机效应模型计算汇总相对风险 (RR) 估计值和相应的 95% 置信区间 (CI)。在有数据的情况下进行亚组分析。涉及 490 322 名参与者的 10 项研究对荟萃分析做出了贡献。基于所有研究的总结 RR 估计并未表明总体 NSAID 的使用显着降低黑色素瘤的风险（RR=0.94；95% CI，0.86-1.03）。使用阿司匹林（RR=0.96；95% CI，0.89-1.03）和非阿司匹林 NSAIDs（RR=1.05；95% CI，0.96-1.14）与黑色素瘤风险无关。队列研究（RR=1.03；95% CI，0.95-1.13）、高强度 NSAID 使用（纳入研究报告的 NSAID 使用最高剂量，RR=1.05；95% CI，0.79-1.40）和长期使用 NSAID（纳入研究报告的 NSAID 使用最长持续时间，RR=0.87；RR=1.05；95% CI，0.79-1.40）的亚组分析也得到了类似的结果。 95% CI，0.66–1.14）。然而，在病例对照研究中观察到服用非甾体抗炎药可略微降低患黑色素瘤的风险（RR=0.86；95% CI，0.80-0.93）。总之，我们的荟萃分析结果并未表明使用非甾体抗炎药或阿司匹林与黑色素瘤的风险相关。未来应该针对这些问题进行更多、更深入的研究。
Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have emerged as potential chemopreventive agents for melanoma. However, the clinical studies have provided contradictory results as to whether NSAIDs reduce the risk of melanoma. Our aim was to assess this association through a detailed meta-analysis of the studies on the subject published in the peer-reviewed literature. Relevant studies were identified by searching PubMed, EMBASE and Web of Science electronic databases up to July 2012. Reference lists from retrieved articles were also reviewed. Pooled relative risk (RR) estimates and corresponding 95% confidence intervals (CIs) were calculated using the fixed-effects or the random-effects models on the basis of heterogeneity analysis. Subgroup analyses were carried out where data were available. Ten studies involving 490 322 participants contributed to the meta-analysis. The summary RR estimate on the basis of all studies did not indicate that overall NSAIDs use significantly decreases the risk of melanoma (RR=0.94; 95% CI, 0.86–1.03). The use of neither aspirin (RR=0.96; 95% CI, 0.89–1.03) nor nonaspirin NSAIDs (RR=1.05; 95% CI, 0.96–1.14) was associated with the risk of melanoma. Similar results were obtained in the subgroup analyses of cohort studies (RR=1.03; 95% CI, 0.95–1.13), high-intensity NSAID use (the highest dose of NSAID use reported by included studies, RR=1.05; 95% CI, 0.79–1.40), and long-term NSAID use (longest duration of NSAID use reported by included studies, RR=0.87; 95% CI, 0.66–1.14). However, a slight reduction in the risk of melanoma by taking NSAIDs was observed in case–control studies (RR=0.86; 95% CI, 0.80–0.93). In conclusion, the results of our meta-analysis did not indicate that the use of NSAIDs or aspirin is associated with the risk of melanoma. More and in-depth research should focus on those problems in the future.
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影响因子：
5.5
作者：
S. Greenland
通讯作者：
S. Greenland
影响因子：
2.9
作者：
E. Hwang;P. Bowen
通讯作者：
E. Hwang;P. Bowen
影响因子：
8.8
作者：
通讯作者：
--
DOI：
10.1016/0021-9681(79)90031-6
发表时间：
1979
期刊：
Journal of Chronic Diseases
影响因子：
--
作者：
R. Horwitz
通讯作者：
R. Horwitz
影响因子：
6.2
作者：
Johannesdottir, Sigrun Alba;Chang, Ellen T.;Sorensen, Henrik Toft
通讯作者：
Sorensen, Henrik Toft