Polymeric biomaterials with degradation sites for proteases involved in cell migration
Polymeric biomaterials with degradation sites for proteases involved in cell migration
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DOI：
10.1021/ma981296k
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发表时间：
1999-01-12
期刊：
影响因子：
5.5
通讯作者：
Hubbell, JA
中科院分区：
文献类型：
--
作者：
West, JL;Hubbell, JA
描述了一类新的可生物降解的聚合物生物材料，其在细胞迁移期间被定位在细胞表面附近的特定酶降解。这些材料是水溶性生物相容性聚合物的遥爪BA B嵌段共聚物、聚乙二醇（A嵌段）和作为靶向酶的切割序列的短寡肽（B嵌段）。这些聚合物在每个末端进一步用反应性丙烯酸酯基团封端，以允许聚合形成交联的水凝胶网络。将两种类型的生物活性信号（一种用于细胞介导的降解，一种用于细胞粘附）组合到一种材料中应实现具有天然细胞外基质性质的仿生聚合物水凝胶。
A new class of biodegradable polymeric biomaterials is described which exhibits degradation by specific enzymes that are localized near cell surfaces during cell migration. These materials are telechelic BAB block copolymers of the water-soluble biocompatible polymer, polyethylene glycol (A block) and short oligopeptide that are cleavage sequences for targeted enzymes (B block). These polymers are further capped at each end with reactive acrylate groups to allow polymerization to form crosslinked hydrogel networks. The combination of two types of bioactive signals, one for cell-mediated degradation, and one for cell adhesion, into one material should achieve a biomemitic polymeric hydrogel with properties of natural extracellular matrix.