Nitric oxide in liver diseases.
Nitric oxide in liver diseases.
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DOI：
10.1016/j.tips.2015.05.001
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发表时间：
2015-08
影响因子：
13.8
通讯作者：
Kim MY
中科院分区：
文献类型：
--
作者：
Iwakiri Y;Kim MY
一氧化氮（NO）及其衍生物在肝脏的生理和病理生理中起着重要作用。尽管NO的作用多种多样且复杂，但仍观察到NO对肝脏疾病的发病机制和进展的某些作用模式。通常，来自肝窦内皮细胞（LSEC）中的内皮NO合酶（eNOS）的NO对疾病发展具有保护作用，而诱导型NOS（iNOS）衍生的NO有助于病理过程。本文综述了NO在各种肝脏疾病发展中的作用，重点是最近发表的文章。我们在这里介绍了两个最近的进展，了解NO介导的信号，硝化脂肪酸和S-鸟苷酸，并得出结论，对未来的方向NO相关的研究对肝脏的建议。
Nitric oxide (NO) and its derivatives play important roles in the physiology and pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. In general, NO derived from endothelial NO synthase (eNOS) in liver sinusoidal endothelial cells (LSECs) is protective against disease development, while inducible NOS (iNOS)-derived NO contributes to pathological processes. This review addresses the roles of NO in the development of various liver diseases with a focus on recently published articles. We present here two recent advances in understanding NO-mediated signaling, nitrated fatty acids and S-guanylation, and conclude with suggestions on future directions of NO-related studies on the liver.