Investigation of emulsified, acid and acid-alkali catalyzed mesoporous bioactive glass microspheres for bone regeneration and drug delivery.
Investigation of emulsified, acid and acid-alkali catalyzed mesoporous bioactive glass microspheres for bone regeneration and drug delivery.
复制标题
DOI：
10.1016/j.msec.2013.06.022
复制
发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Guohou Miao;Xiaofeng Chen;Hua Dong;Liming Fang;Cong Mao;Yu-li Li;Zhengmao Li;Qing Hu
中科院分区：
文献类型：
--
作者：
Guohou Miao;Xiaofeng Chen;Hua Dong;Liming Fang;Cong Mao;Yu-li Li;Zhengmao Li;Qing Hu
采用溶胶-凝胶法和油包水(W/O)微乳液法制备了酸催化介孔生物活性玻璃微球(MBGMS-A)和酸碱共催化介孔生物活性玻璃微球(MBGMS-B)。采用多种测试手段对介孔生物活性玻璃微球的结构、形态和织构特性进行了表征。结果表明，MBGMS-A和MBGMS-B均呈规则球形，但具有不同的内部孔结构，即MBGMS-A具有致密的微结构，MBGMS-B具有较低的二氧化硅网络聚合度。体外生物活性实验表明，在模拟体液(SBF)溶液中浸泡后，MBGMS-B的磷灰石形成速度比MBGMS-A快。此外，两种MBGEM对阿伦磷酸钠(AL)的存储容量相似，并且由于其独特的孔结构，AL的释放行为可以被控制。综上所述，该微球有望作为骨相关药物载体和骨修复复合支架的填充材料。
Acid-catalyzed mesoporous bioactive glass microspheres (MBGMs-A) and acid-alkali co-catalyzed mesoporous bioactive glass microspheres (MBGMs-B) were successfully synthesized via combination of sol-gel and water-in-oil (W/O) micro-emulsion methods. The structural, morphological and textural properties of mesoporous bioactive glass microspheres (MBGMs) were characterized by various techniques. Results show that both MBGMs-A and MBGMs-B exhibit regularly spherical shape but with different internal porous structures, i.e., a dense microstructure for MBGMs-A and internally porous structure for MBGMs-B.29Si NMR data reveal that MGBMs have low polymerization degree of silica network. Thein vitrobioactivity tests indicate that the apatite formation rate of MBGMs-B was faster than that of MBGMs-A after soaking in simulated body fluid (SBF) solution. Furthermore, the two kinds of MBGMs have similar storage capacity of alendronate (AL), and the release behaviors of AL could be controlled due to their unique porous structure. In conclusion, the microspheres are shown to be promising candidates as bone-related drug carriers and filling materials of composite scaffold for bone repair.