The Prohibitins: emerging roles in diverse functions.
The Prohibitins: emerging roles in diverse functions.
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DOI：
10.1111/j.1582-4934.2006.tb00404.x
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发表时间：
2006-04
影响因子：
5.3
通讯作者：
Murphy LJ
中科院分区：
文献类型：
--
作者：
Mishra S;Murphy LC;Murphy LJ
禁止蛋白Phb1和Phb2是真核细胞中高度保守的蛋白，存在于多个细胞区室中。最初的研究集中在Phb1作为细胞增殖抑制剂的作用上，因此原名为prohibitin。然而，这两种蛋白质似乎具有不同的功能范围，最近的证据表明，这两种蛋白具有非常相似的功能，但迄今为止只是部分了解。除了它们在线粒体中作为伴侣蛋白的作用，以及它们靶向脂筏的能力外，现在有令人信服的证据表明，这两种禁止蛋白都位于细胞核中，可以通过直接或间接地与各种转录因子（包括类固醇激素受体）相互作用来调节转录活性。此外，Phb1和Phb2存在于循环中，添加到培养细胞中可被内化，提示循环禁用物可能具有一定的调节作用。本文综述了近年来禁止蛋白研究的一些进展，并重点介绍了这些有趣的蛋白质在结构和功能上的相似性。
The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name prohibitin. However both proteins appear to have a diverse range of functions and recent evidence suggests that the prohibitins have very similar but as yet only partially understood functions. In addition to their role as chaperone proteins in the mitochondria, and their ability to target to lipid rafts, their is now compelling evidence that both prohibitins are localized in the nucleus and can modulate transcriptional activity by interacting with various transcription factors, including the steroid hormone receptors, either directly or indirectly. In addition Phb1 and Phb2 are present in the circulation and can be internalized when added to cultured cells suggesting that the circulating prohibitins may have some regulatory role. This review presents some of the recent developments in prohibitin research and focuses on the similarities in the structure and function of these interesting proteins.
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