Anti-cancer role of SPARC, an inhibitor of adipogenesis.
Anti-cancer role of SPARC, an inhibitor of adipogenesis.
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DOI：
10.1016/j.ctrv.2010.12.001
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发表时间：
2011-11
影响因子：
11.8
通讯作者：
Sharma, Dipali
中科院分区：
文献类型：
--
作者：
Nagaraju, Ganji Puma Chandra;Sharma, Dipali
SPARC(一种酸性和富含半胱氨酸的分泌型蛋白质)是一种强大的抗癌和减肥分子。它是已知的最早调节细胞和细胞外基质(ECM)之间相互作用的基质蛋白之一，与白色脂肪组织(WAT)的平衡以及脂肪生成过程中的脂肪生成和脂肪分解有关。脂肪生成是肥胖发展的一个指征，与多种癌症有关，包括乳腺癌、子宫内膜癌、食道癌等。脂肪生成主要涉及细胞外基质重塑、细胞-细胞外基质相互作用的改变和细胞骨架重排。SPARC还可防止脂肪细胞肥大和脂肪细胞前体细胞的增殖。SPARC除了在脂肪形成中起抑制作用外，还参与细胞周期、细胞增殖、细胞侵袭、黏附、迁移、血管生成和细胞凋亡。分子肿瘤生物学和临床生物化学极大地加深了我们对SPARC抗癌和减肥作用机制的理解。最近的研究阐明了SPARC激活的信号通路，有助于开发SPARC在癌症治疗和肥胖预防方面的有益方面。本文就SPARC在肥胖中的抗癌作用作一综述。
SPARC (a secreted protein acidic and rich in cysteine) has a reputation for being potent anti-cancer and anti-obesity molecule. It is one of the first known matricellular protein that modulates interactions between cells and extracellular matrix (ECM) and is associated with the ‘balance’ of white adipose tissue (WAT) as well as lipogenesis and lipolysis during adipogenesis. Adipogenesis is an indication for the development of obesity and has been related to a wide variety of cancers including breast cancer, endometrial cancer, esophageal cancer, etc. Adipogenesis mainly involves ECM remodeling, changes in cell-ECM interactions, and cytoskeletal rearrangement. SPARC can also prevent hypertrophy of adipocytes and hyperplasia of adipocyte progenitors. In addition to SPARC’s inhibitory role in adipogenesis, it has also been known to be involved in cell cycle, cell proliferation, cell invasion, adhesion, migration, angiogenesis and apoptosis. Molecular cancer biology and clinical biochemistry have significantly enhanced our understanding of the mechanisms that motivate the anti-cancer and anti-obesity action of SPARC. Recent studies elucidating the signaling pathways that are activated by SPARC can help develop the beneficial aspects of SPARC for cancer therapy and obesity prevention. This review focuses on the anti-cancer role of SPARC as it pertains to obesity.
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影响因子：
3.7
作者：
Garzia L;Andolfo I;Cusanelli E;Marino N;Petrosino G;De Martino D;Esposito V;Galeone A;Navas L;Esposito S;Gargiulo S;Fattet S;Donofrio V;Cinalli G;Brunetti A;Vecchio LD;Northcott PA;Delattre O;Taylor MD;Iolascon A;Zollo M
通讯作者：
Zollo M
大肠癌中的SPARC启动子高甲基化可以被5-Aza-2'deoxyCytidine逆转以增加SPARC表达并改善治疗反应。
影响因子：
8.8
作者：
Cheetham, S.;Tang, M. J.;Mesak, F.;Kennecke, H.;Owen, D.;Tai, I. T.
通讯作者：
Tai, I. T.
影响因子：
19.6
作者：
Alpers, CE;Hudkins, KL;Bassuk, JH
通讯作者：
Bassuk, JH
影响因子：
8
作者：
Briggs, J;Chamboredon, S;Bos, TJ
通讯作者：
Bos, TJ
影响因子：
2.9
作者：
ENGEL, J;TAYLOR, W;HOGAN, B
通讯作者：
HOGAN, B