Risk of Infection with Chlamydia trachomatis from Migrants to Communities Undergoing Mass Drug Administration for Trachoma Control.
Risk of Infection with Chlamydia trachomatis from Migrants to Communities Undergoing Mass Drug Administration for Trachoma Control.
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DOI：
10.3109/09286586.2015.1010687
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发表时间：
2015
影响因子：
1.8
通讯作者：
Quinn T
中科院分区：
文献类型：
--
作者：
West SK;Munoz BE;Mkocha H;Gaydos C;Quinn T
为了确定儿童感染沙眼衣原体的风险，他们是移民到正在进行大规模药物管理（MDA）的社区，以及他们的社区是否随着时间的推移有较高的感染率。在坦桑尼亚Kongwa的4个社区，所有儿童都参加了感染和沙眼的纵向研究。新的儿童在人口普查更新时被确定为在上次人口普查时不在社区中。在社区内，邻里被定义为空间上紧密的家庭群体，或“balozi”。社区中的所有儿童都被邀请接受沙眼检查，并采取眼部拭子作为感染证据。使用世界卫生组织简化分级方案对沙眼进行分级，并使用Amplicor处理拭子。流动儿童比社区居民儿童更容易感染沙眼，这在MDA第三年后的调查时具有显著性（比值比，OR，2.49，95%置信区间，CI，1.03-6.05）。新移民居住的社区比没有移民的社区更有可能在一年后感染，这在MDA的第三年后最为明显（OR 2.86，95%CI 1.07-7.65）社区的移民可能是再次出现感染的重要来源，特别是MDA降低了居民中的感染。高度流动人口可能需要一个特殊的监测和治疗计划，以避免减缓社区在MDA下的进展。
To determine the risk of infection with Chlamydia trachomatis in children who are migrants to communities who are undergoing mass drug administration (MDA), and if their neighborhoods have higher rates of infection over time. In 4 communities in Kongwa, Tanzania, all children were enrolled in a longitudinal study of infection and trachoma. New children were identified at census updates as having not been in the community at the previous census. Within communities, neighborhoods were defined as spatially close groups of households, or “balozi”. All children in the communities were invited to be examined for trachoma, and have ocular swabs taken for evidence of infection. Trachoma was graded using the World Health Organization simplified grading scheme, and swabs were processed using Amplicor. Children who were migrants were more likely to be infected and to have trachoma than children who were resident in the community, which was significant by the time of the survey following the third year of MDA (odds ratio, OR, 2.49, 95% confidence interval, CI, 1.03–6.05). The neighborhoods where newcomers resided were more likely to have infection a year later than neighborhoods with no migrants, which was most pronounced following the third year of MDA (OR 2.86, 95% CI 1.07–7.65) Migrants to communities may be an important source of re-emergent infection, especially as MDA lowers infection among residents. Highly migrant populations may need a special surveillance and treatment program to avoid slowing progress in communities under MDA.