The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness.
The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness.
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DOI：
10.2174/138945010791170860
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发表时间：
2010-06
影响因子：
3.2
通讯作者：
Sarkar FH
中科院分区：
文献类型：
--
作者：
Wang Z;Li Y;Kong D;Sarkar FH
Notch信号通路维持细胞增殖和凋亡之间的平衡，因此认为Notch信号通路可能在多种恶性肿瘤的发生和发展中起重要作用。然而，Notch信号在EMT中的功能在很大程度上是未知的。本文简要综述了Notch信号通路在EMT中的作用，以及Notch信号通路的失调如何参与EMT和肿瘤侵袭性。进一步尝试总结了几种化学预防剂的作用，这些化学预防剂可用于Notch信号的靶向失活，从而可能引起EMT的逆转，这可能成为癌症预防和治疗的新方法。
The Notch signaling pathway maintains a balance between cell proliferation and apoptosis, and thus it is believed that Notch signaling pathway may play an important role in the development and progression of several malignancies. However, the functions of Notch signaling in EMT are largely unknown. This mini review describes the role of Notch signaling pathway in EMT, and cataloging how its deregulation is involved in EMT and tumor aggressiveness. Further attempts have been made to summarize the role of several chemopreventive agents that could be useful for targeted inactivation of Notch signaling, and thus it may cause reversal of EMT, which could become a novel approach for cancer prevention and treatment.
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