Pre-morbid human T-lymphotropic virus type I proviral load, rather than percentage of abnormal lymphocytes, is associated with an increased risk of aggressive adult T-cell leukemia/lymphoma
Pre-morbid human T-lymphotropic virus type I proviral load, rather than percentage of abnormal lymphocytes, is associated with an increased risk of aggressive adult T-cell leukemia/lymphoma
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DOI：
10.3324/haematol.2012.069476
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发表时间：
2013-03-01
期刊：
影响因子：
10.1
通讯作者：
Taylor, Graham P.
中科院分区：
文献类型：
--
作者：
Hodson, Andrew;Laydon, Daniel J.;Taylor, Graham P.
在153例新转诊的人类T淋巴细胞病毒I型感染者中，42例(27%)有5%或更多的异常淋巴细胞，与阴燃的成人T细胞白血病/淋巴瘤的诊断一致。人类T淋巴细胞病毒I型相关性炎症性疾病患者的淋巴细胞异常率明显高于无症状携带者(P=0.006)。中位随访超过4.5年，4例患者均出现成人T细胞白血病/淋巴瘤，均为10个或以上人类T淋巴细胞I型DNA拷贝数/100个外周血单核细胞，但仅1例出现异常淋巴细胞5%或以上。因此，高致病前人类T淋巴细胞病毒I型前病毒载量，而不是符合阴燃成人T细胞白血病/淋巴瘤的分类标准，与发生侵袭性成人T细胞白血病/淋巴瘤的风险增加有关。
Out of 153 newly referred human T-lymphotropic virus type I infected patients, 42 (27%) had 5% or more abnormal lymphocytes, consistent with the diagnosis of smoldering adult T-cell leukemia/lymphoma. The abnormal lymphocyte percentage was higher in patients with human T-lymphotropic virus type I associated inflammatory disease compared with asymptomatic carriers (P=0.006). Over 4.5 years median follow up, 4 patients, all with 10 or more human T-lymphotropic virus type I DNA copies/100 peripheral blood mononuclear cells at presentation, but only one with 5% or more abnormal lymphocytes at presentation, developed adult T-cell leukemia/lymphoma. Thus, high pre-morbid human T-lymphotropic virus type I proviral load, rather than fulfilment of the classification criteria for smoldering adult T-cell leukemia/lymphoma, was associated with an increased risk of developing aggressive adult T-cell leukemia/lymphoma.