Specificity of vascular endothelial growth factor treatment for radiation necrosis.
Specificity of vascular endothelial growth factor treatment for radiation necrosis.
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DOI：
10.1016/j.radonc.2015.09.004
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Garbow JR
中科院分区：
文献类型：
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作者：
Perez-Torres CJ;Yuan L;Schmidt RE;Rich KM;Drzymala RE;Hallahan DE;Ackerman JJ;Garbow JR
最近，放射诱发的脑坏死已使用贝伐单抗（一种抗 VEGF 抗体）进行治疗。我们通过比较抗 VEGF 与非特异性同种型对照抗体的治疗效果来验证 VEGF 特异性。此外，我们发现 VEGF 过度表达和 RN 同时发生，这妨碍了预防性抗 VEGF 治疗。
Recently, radiation induced necrosis in the brain has been treated using bevacizumab, an anti-VEGF antibody. We validated the VEGF specificity by comparing the therapeutic efficacy of anti-VEGF with non-specific isotype control antibody. Additionally, we found that VEGF over-expression and RN developed simultaneously, which precludes preventative anti-VEGF treatment.