Transition States of Biochemical Processes
Transition States of Biochemical Processes
复制标题
生化过程的过渡态
DOI：
10.1007/978-1-4684-9978-0
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
R. Schowen
中科院分区：
文献类型：
--
作者：
R. Gandour;R. Schowen
1*过渡态概念的范围和局限性。-2*催化能力和过渡态稳定。-3*研究酶过渡态和反应路径的量子力学方法。-4*初级氢同位素效应。-5*二次氢同位素效应。-6*溶剂氢同位素效应。-7*酶催化反应中的重原子同位素效应。-8*过渡态结构的磁共振方法。-9*从晶体数据绘制反应路径图。-10*酰基和甲基转移中的过渡态性质。-11*缩醛、缩酮、糖苷、糖苷的水解过渡态。和糖基胺。-12*酮酸和相关化合物的脱羧基。-13*磷酸转移的机制。-14*分子内反应和模型的相关性。-15*过渡态亲和力作为设计酶抑制剂的基础。-16*过渡态理论和药物作用和药物设计的反应机制。-作者索引。
1 * Scope and Limitations of the Concept of the Transition State.- 2 * Catalytic Power and Transition-State Stabilization.- 3 * Quantum-Mechanical Approaches to the Study of Enzymic Transition States and Reaction Paths.- 4 * Primary Hydrogen Isotope Effects.- 5 * Secondary Hydrogen Isotope Effects.- 6 * Solvent Hydrogen Isotope Effects.- 7 * Heavy-Atom Isotope Effects in Enzyme-Catalyzed Reactions.- 8 * Magnetic-Resonance Approaches to Transition-State Structure.- 9 * Mapping Reaction Pathways from Crystallographic Data.- 10 * Transition-State Properties in Acyl and Methyl Transfer.- 11 * Transition States for Hydrolysis of Acetals, Ketals, Glycosides, and Glycosylamines.- 12 * Decarboxylations of ?-Keto Acids and Related Compounds.- 13 * The Mechanism of Phosphoryl Transfer.- 14 * Intramolecular Reactions and the Relevance of Models.- 15 * Transition-State Affinity as a Basis for the Design of Enzyme Inhibitors.- 16 * Transition-State Theory and Reaction Mechanism in Drug Action and Drug Design.- Author Index.