Remobilization partially restored the bone mass in a non-growing cancellous bone site following long term immobilization.
Remobilization partially restored the bone mass in a non-growing cancellous bone site following long term immobilization.
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长期固定后，再活动部分恢复了非生长松质骨部位的骨量。
DOI：
10.1016/8756-3282(95)00294-n
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发表时间：
1995
期刊：
影响因子：
4.1
通讯作者：
Yuan,Z
中科院分区：
文献类型：
--
作者：
Ijiri,K;Jee,WS;Ma,YF;Yuan,Z
目前还没有关于大鼠成年骨部位再活动（RM）效果的报道。本研究的目的是确定非生长骨部位（胫骨远端）是否会从 IM 引起的骨质流失中完全恢复。本研究使用了 75 只 6 个月大的处女 Sprague-Dawley 雌性大鼠。他们的后肢用绷带固定在腹部18周，然后重新活动2、10或20周。对距钙化软骨近端 0.3 mm 的前骨骺以及距前骨骺近端 0.3 mm 至 1.92 mm 的前干骺端的小梁骨中的远端胫骨切片进行分析。 IM 后 18 周，前骨骺和干骺端小梁均发生显着骨质流失。 RM 10 周时，丢失的骨质得到部分恢复，但到研究结束时，骨量仍低于衰老对照组。部分恢复的特点是前骨骺骨孔隙度减少和前干骺端小梁增厚，但对骨小梁数量没有影响。我们得出的结论是，在长期 IM 的 20 周 RM 期间，两个远端胫骨区域仅部分恢复。
There is no report in the rat of the effects of remobilization (RM) in an adult bone site. The aim of this study was to determine whether complete recovery from IM-induced bone loss will occur in a non-growing bone site, the distal tibia. Seventy-five 6-month-old virgin Sprague-Dawley female rats were used in this study. Their hindlimbs were immobilized against the abdomen with bandages for 18 weeks, then remobilized for 2, 10 or 20 weeks. Distal tibial sections were analyzed in the former epiphysis, 0.3 mm proximal from the calcified cartilage, and in trabecular bone of the former metaphysis between 0.3 mm and 1.92 mm proximal to the former epiphysis. A significant bone loss occurred in both former epiphyseal and metaphyseal trabeculae at 18 weeks after IM. The lost bone was partially recovered at 10 weeks of RM, but the bone mass was still lower than in aging controls by the end of the study. The partial recovery was characterized by decreasing former epiphyseal bone porosity and thickening of former metaphyseal trabeculae with no effect on trabecular number. We concluded that both distal tibia regions only partially recovered, during 20 weeks of RM from the long time IM.