Gain and Loss of T Cell Subsets in Old Age-Age-Related Reshaping of the T Cell Repertoire
Gain and Loss of T Cell Subsets in Old Age-Age-Related Reshaping of the T Cell Repertoire
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DOI：
10.1007/s10875-010-9499-x
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发表时间：
2011-04-01
影响因子：
9.1
通讯作者：
Grubeck-Loebenstein, Beatrix
中科院分区：
文献类型：
--
作者：
Arnold, Christoph R.;Wolf, Juliane;Grubeck-Loebenstein, Beatrix
免疫系统受到衰老过程的影响，并经历与年龄相关的显著变化，称为免疫衰老。不同的T细胞亚群受此过程的影响。骨髓和胸腺内的改变导致T细胞库的组成从初始T细胞转变为抗原经历的T细胞，从而损害T细胞库的多样性。潜伏性病原体如巨细胞病毒的额外感染加剧了这一过程。在这篇综述中，我们集中在主要的年龄相关的变化，发生在初治和抗原经验丰富的T细胞群。我们讨论了负责这些亚群的产生和维持的机制，以及如何通过临床干预延迟或预防年龄相关的变化。
The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from na < ve to antigen-experienced T cells, thereby compromising the diversity of the T cell pool. Additional infection with latent pathogens such as cytomegalovirus aggravates this process. In this review, we focus on the major age-related changes that occur in the na < ve and the antigen-experienced T cell population. We discuss the mechanisms responsible for the generation and maintenance of these subsets and how age-related changes can be delayed or prevented by clinical interventions.