Stereoselective Cross-Coupling between Allylic Alcohols and Aldimines
Stereoselective Cross-Coupling between Allylic Alcohols and Aldimines
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DOI：
10.1021/ol901006c
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发表时间：
2009-07-16
期刊：
影响因子：
5.2
通讯作者：
Cha, Jin Kun
中科院分区：
文献类型：
--
作者：
Lysenko, Ivan L.;Lee, Hyung Goo;Cha, Jin Kun
报道了烯丙醇与亚胺的交叉偶联反应，用于芳香族和脂肪族亚胺的立体选择性烯丙基化。该方法提供了操作简单，对映体选择性地获得官能化的高烯丙基胺。特别值得注意的是直接使用官能化的烯丙醇作为烯丙基化试剂而不进行预衍生化，这避免了使用预先形成的有机金属试剂或活化的亚胺衍生物。
A cross-coupling reaction between an allylic alcohol and an imine is described for stereoselective allylation of aromatic and aliphatic imines. This method provides operationally simple, enantioselective access to functionalized homoallylic amines. Particularly noteworthy is direct use of a functionalized allylic alcohol as an allylating reagent without prederivatization, which obviates the use of preformed organometallic reagents or activated imine derivatives.