MATCHING MOLECULES IN THE CATCH MECHANISM
MATCHING MOLECULES IN THE CATCH MECHANISM
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DOI：
10.1073/pnas.79.10.3176
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
COHEN, C
中科院分区：
文献类型：
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作者：
COHEN, C
提出了一种新的结构模型来解释软体动物平滑肌的特殊捕获收缩。在这些肌肉的粗细丝中的肌凝蛋白被描绘成由一层分子组成，其组装和活动由潜在的副肌凝蛋白核心控制。这种组织不同于其他肌肉中的肌凝蛋白成束排列。在捕获状态下，肌动蛋白-肌凝蛋白连接的寿命延长，将直接取决于这种特殊的组织，它允许肌凝蛋白的整个棒状区域与副肌凝蛋白核心相互作用。这种相互作用可能由副肌球蛋白的磷酸化调节。
A new structural model is advanced to account for the specialized catch contraction of molluscan smooth muscles. The myosin in the thick filaments of these muscles is pictured as comprising a single layer of molecules whose assembly and activity are controlled by the underlying core of paramyosin. This organization differs from that in other muscles in which the myosin is grouped into bundles. The catch state, in which the lifetime of the actin-myosin linkage is extended, would depend directly on this special organization that allows an interaction of the entire rod region of myosin with the paramyosin core. This interaction might be modulated by phosphorylation of paramyosin.