Increased expression of major histocompatibility complex antigens on lymphocytes from aged mice.
Increased expression of major histocompatibility complex antigens on lymphocytes from aged mice.
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老年小鼠淋巴细胞上主要组织相容性复合物抗原的表达增加。
DOI：
10.1073/pnas.84.21.7624
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发表时间：
1987
影响因子：
11.1
通讯作者：
S. M. Worthen
中科院分区：
文献类型：
--
作者：
C. Sidman;E. Luther;J. D. Marshall;Kim;D. Roopenian;S. M. Worthen
许多研究报告了免疫反应的年龄相关变化，这可能是由于淋巴细胞数量或功能的改变。在这里，我们报告了使用免疫荧光染色和体外细胞功能测定的研究结果，以比较2岁以下小鼠淋巴细胞上细胞表面抗原的表达。脾细胞携带I类或II类主要组织相容性复合体（MHC）抗原、表面免疫球蛋白或Thy-1、Ly-1、Ly-2或L3T4抗原的频率未见显著变化。然而，与年轻小鼠相比，老龄小鼠细胞中I类和II类MHC抗原的密度（每细胞）都显著增加，而其他细胞表面抗原的密度则保持不变或略有下降。与年轻小鼠相比，老年小鼠MHC抗原表达水平的增加在免疫刺激方面具有显著的功能。这些数据表明，在年轻个体中沉默的t细胞克隆可能在老年动物的类似情况下被激活，导致免疫改变，可能包括增加自身反应性。
Many studies have reported age-related changes in immune responses that could be due to alterations in lymphoid cell numbers or functions. Here we report the results of studies using immunofluorescent staining and in vitro assays of cellular function to compare the expression of cell surface antigens on lymphocytes from mice up to 2 years of age. No significant changes were observed in the frequencies of spleen cells bearing class I or class II major histocompatibility complex (MHC) antigens, surface immunoglobulin, or Thy-1, Ly-1, Ly-2, or L3T4 antigens. However, the densities (per cell) of both class I and class II MHC antigens were increased significantly on cells from aged as compared to young mice, whereas the densities of the other cell surface antigens studied were unchanged or slightly decreased. The increased levels of MHC antigen expression in old relative to young mice were shown to be functionally significant regarding immunological stimulation. These data suggest that T-cell clones silent in young individuals may be activated in comparable situations in older animals, leading to immunological alterations perhaps including increased autoreactivity.