THE BRAIN NUCLEUS LOCUS-COERULEUS - RESTRICTED AFFERENT CONTROL OF A BROAD EFFERENT NETWORK
THE BRAIN NUCLEUS LOCUS-COERULEUS - RESTRICTED AFFERENT CONTROL OF A BROAD EFFERENT NETWORK
复制标题
DOI：
10.1126/science.3775363
复制
发表时间：
1986-11-07
期刊：
影响因子：
56.9
通讯作者：
SHIPLEY, MT
中科院分区：
文献类型：
--
作者：
ASTONJONES, G;ENNIS, M;SHIPLEY, MT
在大鼠蓝斑密集、局部注射麦芽凝集素结合的辣根过氧化物酶，标记了出乎意料的少数脑区的传入神经元。主要的输入只来自两个核--巨细胞旁核和舌下前置核，两者都位于延髓吻部。下丘脑室旁核的背帽和脊髓中间灰质可能是蓝斑的次要传入。其他被报道投射到蓝斑的区域(例如杏仁核、孤束核和脊髓背角)没有显示一致的逆行标记。顺行追踪和电生理实验证实，这些区域没有输入到蓝斑，而是终止于与蓝斑相邻的靶点。这些发现重新定义了蓝斑的解剖结构，并对有关去甲肾上腺素能脑核功能的假说有一定的意义。
Dense, focal injections of wheat germ agglutinin conjugated-horseradish peroxidase in the locus coeruleus of rats labeled afferent neurons in unexpectedly few brain regions. Major inputs emanate from only two nuclei-the paragigantocellularis and the prepositus hypoglossi, both in the rostral medulla. The dorsal cap of the paraventricular hypothalamis nucleus and the spinal intermediate gray are possible minor afferents to locus coeruleus. Other areas reported to project to locus coeruleus (for example, amygdala, nucleus tractus solitarius, and spinal dorsal horn) did not exhibit consistent retrograde labeling. Anterograde tracing and electrophysiologic experiments conifirmed the absence of input to locus coeruleus from these areas, which instead terminate in targets adjacent to locus coeruleus. These findings redefine the anatomic organization of the locus coeruleus, and have implications for hypotheses concerning the functions of this noradrenergic brain nucleus.