Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool
Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool
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DOI：
10.1038/nn1831
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发表时间：
2007-02-01
影响因子：
25
通讯作者：
Klingauf, Jurgen
中科院分区：
文献类型：
--
作者：
Groemer, Teja W.;Klingauf, Jurgen
最近，有人声称，囊泡回收自发和活动期间属于不同的池。在这里，我们同时测量，使用光谱可分离的苯乙烯基染料，释放动力学的囊泡回收自发或刺激后的影响和V-ATP酶阻断剂福利霉素的频率上的微型突触后电流在大鼠海马神经元。我们的研究结果提供了证据的身份的囊泡池回收在休息和刺激。
Recently, it has been claimed that vesicles recycling spontaneously and during activity belong to different pools. Here we simultaneously measured, using spectrally separable styryl dyes, the release kinetics of vesicles recycled spontaneously or upon stimulation and the effects of the v-ATPase blocker folimycin on the frequency of miniature postsynaptic currents in rat hippocampal neurons. Our results provide evidence as to the identities of the vesicle pools recycling at rest and during stimulation.