A new phenyl 6,7-dihydroxygeranyl ether derivative from a marine-derived fungus strain of Penicillium arabicum ZH3-9.
A new phenyl 6,7-dihydroxygeranyl ether derivative from a marine-derived fungus strain of Penicillium arabicum ZH3-9.
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DOI：
10.1080/14786419.2023.2169917
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发表时间：
2023-01
影响因子：
2.2
通讯作者：
Jinpeng Yang;Xinwan Zhang;Wei Xu;Xiuli Xu;Fuhang Song
中科院分区：
文献类型：
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作者：
Jinpeng Yang;Xinwan Zhang;Wei Xu;Xiuli Xu;Fuhang Song
从广东珠海沿海的一株海洋来源的阿拉伯青霉ZH3-9中分离得到一种新的苯基6,7-二羟基香叶醚衍生物，命名为(Z)-4-(（6,7-二羟基3,7-二甲基-2-烯-1-基）氧基苯甲酸(1)和8个已知化合物（2-9）。1的结构通过hresms、1d和2d NMR进行了表征。所有化合物对白色念珠菌、金黄色葡萄球菌和大肠杆菌的抑菌活性进行了评价。化合物4 ~ 6对金黄色葡萄球菌具有抑菌活性，最低抑菌浓度分别为50、12.5和50 μg/mL。
A new phenyl 6,7-dihydroxygeranyl ether derivative, named (Z)-4-((6,7-dihydroxy-3,7-dimethyloct-2-en-1-yl)oxy)benzoic acid (1), and 8 known compounds (2-9) were characterized from a marine-derived fungus strain of Penicillium arabicum ZH3-9 isolated from a mud sample collected from the coast of Zhuhai, Guangdong Province, China. The structure of 1 was elucidated by HRESIMS, 1 D and 2 D NMR. All compounds were evaluated antimicrobial activities against Candida albicans, Staphylococcus aureus, and Escherichia coli. Compounds 4-6 displayed antibacterial activity against S. aureus with minimum inhibitory concentrations of 50, 12.5, and 50 μg/mL.