Nephroimmunopathology and pathophysiology.
Nephroimmunopathology and pathophysiology.
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肾免疫病理学和病理生理学。
DOI：
10.1152/ajprenal.1985.248.3.f319
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Blantz,RC
中科院分区：
文献类型：
--
作者：
Wilson,CB;Blantz,RC
肾损伤的免疫学模型在病理生理学研究中是有用的。这些模型中的一些已经被用于肾小球微穿刺研究，并被证明是接近与研究正常肾功能的相同技术。在这些研究中发现的肾小球渗透系数的典型降低被静水压力梯度的增加所抵消，从而使单个肾单位滤过率的降低最小化。涉及抗体的直接肾小球（和肾小管）固定或免疫复合物物质积累的抗体机制提供了一系列急性和慢性病变，用于评估与人体免疫肾小球和肾小管病变相关的大部分。不同的和重叠的免疫介质系统的影响也是生理评估的有用领域。肾脏免疫病理学家的工具可能有助于生理学家识别和定位对肾功能至关重要的转运系统的影响。熟练的免疫学，病理学和生理学研究人员的协作互动是必要的，以实现最佳的科学价值。
Immunologic models of renal injury are useful in the study of pathophysiology. Some of these models have already been used in glomerular micropuncture studies and were shown to be approachable with the same techniques that were developed to study normal renal function. The typical decrease in the glomerular permeability coefficient found in such studies is countered by an increase in the hydrostatic pressure gradient, minimizing decreases in single nephron filtration rate. Antibody mechanisms involving either direct glomerular (and tubular) fixation of antibody or accumulation of immune complex materials provide an array of acute and chronic lesions for evaluation with relevance to the bulk of immune glomerular and tubular lesions in humans. The influences of varied and overlapping immune mediator systems are also useful areas for physiologic assessment. The tools of the renal immunopathologist may be useful to the physiologist in identifying and localizing the effects of transport systems central to renal function. The collaborative interaction of investigators skilled in immunology, pathology, and physiology is necessary to achieve optimum scientific value.