Regional rates of glucose utilization in the cat following concussive head injury.
Regional rates of glucose utilization in the cat following concussive head injury.
复制标题
脑震荡后猫的葡萄糖利用率的区域性。
DOI：
10.1089/neu.1988.5.121
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发表时间：
1988
影响因子：
4.2
通讯作者：
Young,HF
中科院分区：
文献类型：
--
作者：
Hayes,RL;Katayama,Y;Jenkins,LW;Lyeth,BG;Clifton,GL;Gunter,J;Povlishock,JT;Young,HF
注射[14 C]-脱氧葡萄糖（[14 C]DG）用于研究对照猫和受液压冲击装置产生的脑震荡损伤猫的局部脑葡萄糖利用率（LCGU）。对不同动物组的研究表明，所选损伤水平产生短暂的行为抑制，可能与创伤性意识障碍有关。LCGU采样的位置附近的液压冲击损伤和更尾部的脑桥区域。组织学研究检查了计算LCGU的区域内出血、挫伤或血脑屏障破坏的可能性。这些研究产生的分析表明：（1）[14 C]DG技术可以有效地应用于推断脑震荡后脑活动区域水平的变化，（2）脑震荡损伤产生脑功能的变化，这些变化在中枢神经系统的各个区域之间可靠地不同，可能包括抑郁症和特定脑部位的局灶性激活。数据进行了讨论，表明在特定区域的脑活动的变化表明，在LCGU的变化可能会导致急性神经功能障碍脑震荡后，包括无意识。
Injections of [14C]-deoxyglucose ([14C]DG) were used to study rates of local cerebral glucose utilization (LCGU) in control cats and cats subjected to concussive brain injury produced by a fluid–percussion device. Studies in separate groups of animals demonstrated that the injury level selected produced transient behavioral suppression probably associated with traumatic disturbances of consciousness. LCGU was sampled near the site of fluid–percussion injury and more caudally in pontine regions. Histopathologic studies examined the possibility of hemorrhage, contusion, or breakdown of the blood–brain barrier in regions within which LCGU was calculated. These studies yielded analyses indicating that (1) the [14C]DG technique can be applied usefully to infer changes in regional levels of brain activity after concussion, (2) concussive injury produces changes in brain function that differ reliably across various regions of the central nervous system and may include both depression and focal activation of specific brain sites. Data are discussed that suggest that changes in brain activity in specific regions indicated by changes in LCGU could contribute to acute neurologic disturbances after concussion including unconsciousness.