Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen.
Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen.
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硒有机化合物依布硒啉抑制豚鼠多形核白细胞产生超氧阴离子。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
H. Masayasu
中科院分区：
文献类型：
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作者：
S. Ichikawa;K. Omura;T. Katayama;N. Okamura;T. Ohtsuka;S. Ishibashi;H. Masayasu
具有谷胱甘肽过氧化物酶样活性的硒有机化合物2-苯基-1,2-苯并异硒唑-3(2H)- 1 （Ebselen）显著抑制了乙酸十四烷醇（TPA）诱导的完整豚鼠多形核白细胞（PMNL）超氧阴离子（O2-）的产生。该化合物几乎完全抑制了由tpa处理的PMNL在低至250 nM浓度下制备的颗粒组分的O2-产生。
Production of superoxide anion (O2-) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O2- production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.