EARLY EFFECTS OF CORTICOSTEROIDS ON BASOPHILS, LEUKOCYTE HISTAMINE, AND TISSUE HISTAMINE
EARLY EFFECTS OF CORTICOSTEROIDS ON BASOPHILS, LEUKOCYTE HISTAMINE, AND TISSUE HISTAMINE
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DOI：
10.1016/0091-6749(79)90217-3
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发表时间：
1979-01-01
影响因子：
14.2
通讯作者：
LEVY, DA
中科院分区：
文献类型：
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作者：
DUNSKY, EH;ZWEIMAN, B;LEVY, DA
在11名特应性受试者中，对单次静脉注射甲基强的松龙对血液嗜酸性粒细胞、嗜碱性粒细胞、白细胞对组胺释放抗原的敏感性、白细胞组胺含量和皮肤组胺的连续研究的比较效果进行了检查。安慰剂治疗后，任何参数均未发生显著变化。相反，在用类固醇静脉内治疗后4小时，平均嗜酸性粒细胞计数（~ 95%）、嗜碱性粒细胞计数（~ 72%）和组胺含量显著降低1.5倍。107份白细胞样本（-62%）。后者的时间变化导致循环嗜碱性粒细胞水平的改变。抗原组胺释放敏感性和皮肤组胺总量无明显变化。在4例受试者中进行的类固醇给药后较长时间的研究显示，嗜酸性粒细胞和嗜碱性粒细胞水平在8 h时达到最低点，持续抑制24 h，并在72 h时恢复至治疗前水平。由于嗜碱性粒细胞的耗竭，皮质类固醇明显诱导白细胞组胺的显著降低，而每个嗜碱性粒细胞的组胺含量没有降低，并且皮肤组织组胺储存显然通过这种治疗保持不变。
The comparative effect in 11 atopic subjects of a single i.v. injection of methylprednisolone on sequential studies of blood eosinophils, basophils, leukocyte sensitivity to antigen for histamine release, leukocyte histamine content and skin histamine was examined. No significant changes occurred in any parameter after placebo treatment. In contrast, 4 h after i.v. treatment with steroid there were significant decreases in mean eosinophil counts (-95%), basophil counts (-72%) and histamine content of 1 .times. 107 leukocyte samples (-62%). Temporal changes in the latter paralleled alterations in circulating basophil levels. No significant changes occurred in the antigen histamine release sensitivity or the total skin histamine. Studies over a longer period after steroids in 4 subjects showed eosinophil and basophil levels at a nadir at 8 h, remaining suppressed for 24 h and returned to pretreatment levels by 72 h. Corticosteroids apparently induce a prominent decrease in leukocyte histamine due to a depletion of basophils without a decrease in histamine content per basophil, and skin tissue histamine stores apparently remain unchanged by such treatment.