Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism.
Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism.
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BAF60a/BAF60c 在染色质重塑和肝脂质代谢中的作用
DOI：
10.1186/s12986-016-0090-1
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发表时间：
2016
影响因子：
4.5
通讯作者：
Huang F
中科院分区：
文献类型：
--
作者：
Zhang P;Li L;Bao Z;Huang F
转换缺陷/蔗糖非发酵(SWI/SNF)复合体在肝脏脂代谢中发挥重要作用，调节转录激活和抑制。BAF60a是SWI/SNF染色质重塑复合体的核心亚单位，在空腹/胰高血糖素过程中激活脂肪酸氧化基因的转录。BAF60c是SWI/SNF复合体的另一个亚基，被招募来形成LipoBAF复合体，该复合体激活脂肪生成基因，促进脂肪生成，并增加甘油三酯水平，以响应喂养/胰岛素。有趣的是，位于肝脏门静脉周围和周围静脉区的肝细胞在各种酶的活性、代谢功能和基因表达方面表现出显著的异质性。特别是，脂肪酸氧化主要发生在门静脉周围，而脂肪生成主要发生在静脉周围。因此，本文综述了SWI/SNF在营养和激素调控下调节脂代谢的作用，这可能与肝细胞的异质性有关。
The switching defective/sucrose non-fermenting (SWI/SNF) complexes play an important role in hepatic lipid metabolism regulating both transcriptional activation and repression. BAF60a is a core subunit of the SWI/SNF chromatin-remodeling complexes that activates the transcription of fatty acid oxidation genes during fasting/glucagon. BAF60c, another subunit of SWI/SNF complexes, is recruited to form the lipoBAF complex that activates lipogenic genes, promoting lipogenesis and increasing the triglyceride level in response to feeding/insulin. Interestingly, hepatocytes located in the periportal and perivenous zones of the liver display a remarkable heterogeneity in the activity of various enzymes, metabolic functions and gene expression. Especially, fatty-acid oxidation was shown to be mostly periportal, whereas lipogenesis was mostly perivenous. Therefore, the present review highlights the role of of SWI/SNF regulating lipid metabolism under nutritional and hormonal control, which may be associated with hepatocyte heterogeneity.