E-cadherin expression in the primary tumors and metastatic lymph nodes of poorly differentiated types of rectal cancer
E-cadherin expression in the primary tumors and metastatic lymph nodes of poorly differentiated types of rectal cancer
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DOI：
10.1007/s005950200004
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发表时间：
2002-01-01
期刊：
影响因子：
2.5
通讯作者：
Fukao, K
中科院分区：
文献类型：
--
作者：
Kanazawa, N;Oda, T;Fukao, K
目的.细胞间粘附分子E-钙粘蛋白功能障碍与直肠癌的去分化和/或侵袭性相关。然而，E-cadherin在原发肿瘤中的表达与转移潜能之间的关系从未被证实。E-cadherin在43例原发性直肠癌（包括10例低分化型）及其相关淋巴结转移中的表达结果：异质性免疫染色，提示E-钙粘蛋白介导的细胞-细胞粘附系统的损伤，在28个LN转移瘤阳性原发灶中的13个中观察到，但在15个LN转移瘤阴性原发灶中的0个中观察到。此外，异质性免疫染色的发生率在低分化癌和分化癌之间存在显著差异，分别见于10例中的8例和33例中的5例（Fisher精确检验P = 0.0003）。有趣的是，大多数LN转移。28例中有25例E-cadherin染色均匀，与原发灶的E-cadherin染色模式无关。低分化直肠癌中E-钙粘蛋白的不均一免疫染色与淋巴结转移有关。然而，其在转移性淋巴结中的染色模式通常是均匀的。
Purpose. Dysfunction of E-cadherin, a cell-cell adhesion molecule, correlates with the grade of dedifferentiation and/or invasiveness of rectal cancer. However, the relationship between E-cadherin expression in the primary tumor and the potential for metastasis has never been reported.Methods. E-cadherin expression in 43 primary rectal cancer, including 10 poorly differentiated type, and their associated metastatic lymph nodes (LN mets.) were immunohistochemically evaluated.Results. Heterogeneous immunostaining, suggestive of damage to the E-cadherin-mediated cell-cell adhesion system, was seen in 13 of the 28 LN mets positive primary lesions, but in 0 of the 15 LN mets negative primaries. Furthermore, the incidence of heterogeneous immunostaining differed significantly between poorly differentiated and differentiated cancers, being seen in 8 of 10 cases and 5 of 33 cases, respectively (P = 0.0003 by Fisher's exact test). Interestingly, most of the LN mets. foci (25 of 28 cases) showed homogeneous staining regardless of the E-cadherin staining pattern of the primary lesion.Conclusion. Heterogeneous immunostaining of E-cadherin in poorly differentiated rectal cancer was associated with lymph node metastasis. Its staining pattern in metastatic lymph nodes were, however, generally homogenous.