Impaired fronto-temporal processing of emotion in schizophrenia
Impaired fronto-temporal processing of emotion in schizophrenia
复制标题
DOI：
10.1016/j.neucli.2007.04.001
复制
发表时间：
2007-04-01
影响因子：
3
通讯作者：
Krolak-Salmon, P.
中科院分区：
文献类型：
--
作者：
Bediou, B.;Henaff, M.-A.;Krolak-Salmon, P.
目标。- 精神分裂症的异常情绪处理影响社会和功能结果。这种缺陷背后的时空脑机制尚不清楚。材料与方法。- 比较了10名健康志愿者和10名精神分裂症患者在内隐（性别检测）和外显（表情检测）任务中对情绪和中性面孔加工的事件相关电位（ERP）反应。- 而患者有正常的初级视觉皮层反应，枕叶，颞叶和额叶反应的早期调制的情绪表达中观察到的控制是不存在的患者。在表达检测期间，患者的枕颞N170振幅相对于对照降低，但在性别检测期间不降低。与对照组相比，患者在180-250 ms内的额叶活动减少。与对照组相比，患者在右侧颞叶电极（T6）上不同情绪诱发的长潜伏期ERP的波幅无显著差异。- 在精神分裂症患者中，枕颞叶皮层（170 ms前）中表达相关信息的异常早期提取损害了面部表情的结构编码（N170），并可能破坏与表情相关的面部特征的动机和任务依赖性上下文处理（180- 250 ms时间窗）。此外，从额叶和边缘结构到视觉枕颞皮层的自上而下的神经调节可能不足以优化表情特异性面部特征的提取。(c)2007年，Elsevier Masson SAS。All rights reserved.
Aims. - Abnormal emotion processing in schizophrenia affects social and functional outcome. Spatiotemporal brain mechanisms underlying this deficit are unclear.Materials and methods. - Event-related potential (ERP) responses to emotional and neutral face processing during an implicit (gender detection) and an explicit (expression detection) task were compared between a group of healthy volunteers (n = 10) and a group of patients with schizophrenia (n = 10).Results. - Whereas patients had normal primary visual cortex responses, the early modulation of occipital, temporal, and frontal responses by emotional expression observed in controls was absent in patients. The occipito- temporal N170 amplitude was reduced in patients relative to controls during expression detection, but not during gender detection. Frontal activity within 180-250 ms was reduced in patients compared to controls. As opposed to controls, no significant difference was seen in patients at the right temporal electrode (T6) between amplitudes of long-latency ERPs elicited by distinct emotions during the expression detection task.Conclusion. - In patients with schizophrenia, abnormal early extraction of expression-related information in the occipito-temporal cortex (before 170 ms) impairs structural encoding of facial expressions (N170) and may disrupt motivation- and task-dependent context processing (180-250ms time window) of expression-related facial features. Moreover, top-down neuro-modulation from frontal and limbic structures to visual occipito-temporal cortex may not be sufficient to optimize the extraction of expression-specific face features. (c) 2007 Elsevier Masson SAS. All rights reserved.