ISCHEMIC DAMAGE IN THE STRIATUM OF ADULT GERBILS - RELATIVE SPARING OF SOMATOSTATINERGIC AND CHOLINERGIC INTERNEURONS CONTRASTS WITH LOSS OF EFFERENT NEURONS
ISCHEMIC DAMAGE IN THE STRIATUM OF ADULT GERBILS - RELATIVE SPARING OF SOMATOSTATINERGIC AND CHOLINERGIC INTERNEURONS CONTRASTS WITH LOSS OF EFFERENT NEURONS
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DOI：
10.1016/0014-4886(90)90032-n
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发表时间：
1990-11-01
影响因子：
5.3
通讯作者：
JIN, BK
中科院分区：
文献类型：
--
作者：
CHESSELET, MF;GONZALES, C;JIN, BK
在短暂前脑缺血后4天和7天，用组织化学方法检查成年沙鼠纹状体中缺血诱导的细胞死亡模式。结果显示，脑啡肽和速激肽（纹状体传出神经元中存在的肽）的免疫反应性大量丧失。相反，表达乙酰胆碱酯酶活性或胆碱乙酰转移酶免疫反应性的神经元以及神经元免疫反应性生长抑素在严重神经元损失的区域中相对保留。成人纹状体神经元亚群对短暂性缺血的选择性脆弱性与在新生儿和局部注射 N-甲基-D-天冬氨酸受体激动剂中观察到的相似，但与其他谷氨酸受体亚型激动剂不同。它还与亨廷顿病中观察到的神经元死亡模式惊人相似。结果进一步支持了兴奋性氨基酸受体亚型的过度刺激在缺血诱导的细胞死亡中的作用，并表明缺血性损伤后纹状体中间神经元亚群的选择性保留与这些神经元的不成熟无关，但也发生在成人中。
The pattrn of ischemia-induced cell death was examined with histochemical methods in the striatum of adult gerbils 4 and 7 days after transient forebrain ischemia. The results showed a massive loss of immunoreactivity to enkephalin and tachykinins, peptides present in striatal efferent neurons. In contrast, neurons expressing acetylcholinesterase activity, or choline acetyltransferase immunoreactivity as well as neurons immunoreactive somatostatin, were relatively preserved in areas of severe neuronal loss. The selective vulnerability of subpopulations of striatal neurons to transient ischemia in the adult is similar to that observed in the neonate and afterlocal injections of agonists of N-methyl-D-aspartate receptors, but not of agonists of othr glutamate receptor subtypes. It also presents striking similarities to the pattern of neuronal death observed in Huntington''s disease. The results further support a role for overstimulation of a subtype of excitatory amino acid receptor in ischemia-induced cell death and show that the selective sparing of subpopulations of striatal interneurons after ischemic injury is not related to immaturity of these neurons but also occurs in the adult.