Role of functional MR in determining language dominance in epilepsy and nonepilepsy populations: A Bayesian analysis
Role of functional MR in determining language dominance in epilepsy and nonepilepsy populations: A Bayesian analysis
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DOI：
10.1148/radiol.2421050677
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发表时间：
2007-01-01
期刊：
影响因子：
19.7
通讯作者：
Ruiz, Jeniffer
中科院分区：
文献类型：
--
作者：
Medina, L. Santiago;Bernal, Byron;Ruiz, Jeniffer
目的：为了确定功能磁共振成像（MR）在评估癫痫和nonepilepsy populations.Materials半球语言优势的作用：贝叶斯分析研究。本研究基于已发表文献的数据;因此，无需机构审查委员会批准。通过回顾文献，获得前测概率和似然比，并使用功能磁共振成像对其进行分析，以确定语言优势的后测概率。癫痫和非癫痫人群中不同手优势的预检验概率来自文献中最大的研究。结果：以皮层电刺激（ECS）和Wada测验为参考标准，功能性MR判断语言优势的Likewise比分别为9.3和12.3。使用功能性MR增加了癫痫和非癫痫人群半球语言优势的最终后测概率。在非癫痫人群中，无论手优势如何，功能性MR半球激活和明确的左半球语言优势之间的相关性有很高的后测概率（>= 96%）。在右手优势或双手灵巧的癫痫人群中，功能性MR半球激活和明确的左半球语言优势之间的相关性有非常高的后测概率（>= 95%）。在左撇子非癫痫受试者中，功能性MR半球激活和明确的右半球语言优势之间的相关性有很高的后测概率（81%-83%）。在左撇子癫痫人群中，有高的后验概率（80%-97%）的功能MR半球激活和明确的右半球和双边语言dominance.Conclusion之间的相关性：使用功能MR增加重要的后验概率半球语言优势在多个亚组的个人和没有癫痫。
Purpose: To determine the role of functional magnetic resonance (MR) imaging in assessing hemispheric language dominance in epilepsy and nonepilepsy populations.Materials and methods: A Bayesian analysis study was performed. The study was based on data from the published literature; thus, institutional review board approval was not required. The literature was reviewed to obtain pretest probabilities and likelihood ratios, which were analyzed to determine the posttest probability of language dominance by using functional MR imaging. Pretest probabilities of different hand dominances in epilepsy and nonepilepsy populations were obtained from the largest studies available in the literature. Likelihood ratios were derived from the sensitivity and specificity of functional MR imaging by using electrocortical stimulation (ECS) and the Wada test as reference standards.Results: Likelihood ratios for functional MR in determining language dominance were 9.3 and 12.3 with ECS and the Wada test as reference standards, respectively. Use of functional MR increased the final posttest probabilities of hemispheric language dominance in epilepsy and nonepilepsy populations. In the nonepilepsy population,regardless of hand dominance, there was very high posttest probability (>= 96%) of a correlation between functional MR hemisphere activation and definite left-hemisphere language dominance. In the epilepsy population with right-hand dominance or ambidexterity, there was very high posttest probability (>= 95%) of a correlation between functional MR hemisphere activation and definite left-hemisphere language dominance. In the left-handed nonepileptic subjects, there was high posttest probability (81%-83%) of a correlation between functional MR hemisphere activation and definite right-hemisphere language dominance. In the left-handed epilepsy population, there was high posttest probability (80%-97%) of correlations between functional MR hemisphere activation and both definite right-hemisphere and bilateral language dominance.Conclusion: Use of functional MR increases importantly the posttest probabilities of hemispheric language dominance in multiple subgroups of individuals with and without epilepsy.