Development of B-cell lymphoma in homosexual men. Clinical and immunologic findings.
Development of B-cell lymphoma in homosexual men. Clinical and immunologic findings.
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男性同性恋者发生 B 细胞淋巴瘤。
DOI：
10.7326/0003-4819-100-1-7
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发表时间：
1984
影响因子：
39.2
通讯作者：
R. Lukes
中科院分区：
文献类型：
--
作者：
A. Levine;P. Meyer;M. K. Begandy;J. Parker;C. Taylor;L. Irwin;R. Lukes
严重的感染，肿瘤和免疫异常已被发现在同性恋男子。我们描述了恶性淋巴瘤的发展，在六个这样的病人，其中三人有持续的，广泛的淋巴结肿大。在淋巴瘤发生前进行的活检中，淋巴结病的形态学特征是B细胞滤泡增生的独特模式。所有淋巴瘤均为B淋巴细胞源性，包括B细胞免疫母细胞肉瘤、小无裂伯基特样淋巴瘤和浆细胞样淋巴细胞淋巴瘤。5例患者出现结外表现伴B症状。患者的平均年龄为33岁。3例患者有反复全身感染史。4例患者外周血淋巴细胞计数下降，OKT 4+（辅助表型）细胞水平下降，辅助T细胞：抑制T细胞比例逆转。我们的结论是，这些患者有发展异常的B淋巴细胞系统的风险，表现为异常超B细胞反应，在扩大的反应性淋巴结和侵略性，淋巴结B细胞淋巴瘤。
Serious infections, neoplasms, and immunologic abnormalities have been found in homosexual men. We describe the development of malignant lymphoma in six such patients, three of whom had persistent, generalized lymphadenopathy. In biopsies done before the lymphoma developed, the lymphadenopathy was characterized morphologically by a distinctive pattern of B-cell follicular hyperplasia. All lymphomas were of B-lymphocytic origin, including B-cell immunoblastic sarcoma; small noncleaved, Burkitt-like lymphoma; and plasmacytoid lymphocytic lymphoma. Extranodal presentation with B symptoms occurred in five patients. Median age of our patients was 33 years. Three patients had histories of repeated systemic infections. The peripheral blood lymphocyte count was depressed in four, with depression of OKT 4+ (helper phenotype) cell levels and reversal of the T-helper: T-suppressor ratio in all. We conclude that these patients are at risk for the development of abnormalities of the B-lymphocytic system, manifested by abnormal hyper-B-cell response in enlarged reactive lymph nodes and aggressive, extranodal B-cell lymphomas.
一名先前健康的典型血友病患者出现获得性免疫缺陷综合征，伴有卡氏肺孢子虫肺炎和鸟分枝杆菌细胞内感染。
影响因子：
39.2
作者：
Poon,MC;Landay,A;Prasthofer,EF;Stagno,S
通讯作者：
Stagno,S