Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors
Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors
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DOI：
10.1038/nmat1270
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发表时间：
2005-01-01
期刊：
影响因子：
41.2
通讯作者：
Velev, OD
中科院分区：
文献类型：
--
作者：
Millman, JR;Bhatt, KH;Velev, OD
微流体装置和生物阵列中的化学和生物过程的小型化是一项重大的技术成就。执行多相材料合成操作的微芯片可能是这一趋势的未来步骤。在这里，我们将展示电控芯片如何用于合成和操纵具有先进结构的新型粒子。该方法是基于一种技术，允许自由悬浮液滴和颗粒被捕获和使用电场运输。保持和引导液滴和颗粒的场通过浸没在油中的电极阵列施加。悬浮在氟化液体表面上的每个微滴充当微观反应器，其中通过载体液滴的固化形成颗粒。控制芯片上的组装，干燥，封装和聚合被用来使各向异性的“眼球”和条纹颗粒，聚合物胶囊和半导体微珠。
The miniaturization of chemical and biological processes in microfluidic devices and bioarrays is a major technological achievement. Microchips performing multiphase material synthesis operations could be a future step in this trend of miniaturizing technology. Here we show how electrically controlled chips can be used for the synthesis and manipulation of new types of particles with advanced structure. The method is based on a technique that allows freely suspended droplets and particles to be entrapped and transported using electric fields. The fields that hold and guide the droplets and particles are applied through arrays of electrodes submerged in the oil. Each of the microdroplets suspended on the surface of fluorinated liquid serves as a microscopic reactor, where the particles are formed by solidification of the carrier droplets. Controlled on-chip assembly, drying, encapsulation and polymerization were used to make anisotropic 'eyeball' and striped particles, polymer capsules and semiconducting microbeads.