Determinants of intestinal detoxication of lipid hydroperoxides
Determinants of intestinal detoxication of lipid hydroperoxides
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DOI：
10.3109/10715769809065819
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发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Aw, TY
中科院分区：
文献类型：
--
作者：
Aw, TY
人们早就认识到氢过氧化物是细胞毒性剂。然而，近年来，越来越明显的是，脂质过氧化氢可能在介导导致肠道疾病（如癌症）的退行性病理生理过程中的细胞和分子事件中发挥重要作用。然而，令人惊讶的是，很少有人知道过氧化脂质的肠道处置和决定粘膜过氧化物消除的代谢因素。本文总结了还原剂（GSH和NADPH）在肠道过氧化氢解毒中的关键作用的证据。这一信息将提供重要的见解管腔脂质氢过氧化物和肠道GSH氧化还原稳态之间的关系，是有关了解如何饮食氧化剂，如脂质过氧化物，可以影响肠道完整性与肠道病理的起源的影响。
It has long been recognized that hydroperoxides are agents of cytotoxicity. However, in recent years, it is increasingly apparent that lipid hydroperoxide may play an important role in mediating cellular and molecular events in degenerative pathophysiological processes that lead to intestinal disorders, such as cancer. Yet, surprisingly little is known of the intestinal disposition of peroxidized lipids and of the metabolic factors that determine mucosal peroxide elimination. The present paper summarizes the evidence for the pivotal role of reductant (GSH and NADPH) availability in intestinal peroxide detoxication. This information will provide important insights into the relationship between luminal lipid hydroperoxides and intestinal GSH redox homeostasis, and is pertinent to understanding how dietary oxidants like lipid peroxides, can impact intestinal integrity with implications for genesis of gut pathology.