Remodeling the brain with behavioral experience after stroke.
Remodeling the brain with behavioral experience after stroke.
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DOI：
10.1161/strokeaha.108.533653
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发表时间：
2009-03
期刊：
影响因子：
8.3
通讯作者：
Maldonado MA
中科院分区：
文献类型：
--
作者：
Jones TA;Allred RP;Adkins DL;Hsu JE;O'Bryant A;Maldonado MA
行为经验可以驱动大脑可塑性，但我们缺乏足够的知识来优化中风后的治疗用途。我们概述了最近的研究结果，从啮齿动物模型的皮质中风的经验如何与损伤后的事件相互作用，影响突触连接和功能的结果，重点是上肢功能。单侧皮质梗死后，行为经验塑造了两个半球的神经元结构和活动。重要的经验包括干预措施，如技能培训和强制性治疗，以及非指导性行为，如学习性不使用和行为补偿。偏侧化行为具有双半球影响。缺血性损伤可以改变剩余的新皮层神经元对行为变化的敏感性，这可以具有积极和消极的功能影响。由于中风幸存者的经验是持续的，因此需要更好地了解其与大脑重组的相互作用，以便可以操纵它来改善功能并防止其恶化。
Behavioral experience can drive brain plasticity, but we lack sufficient knowledge to optimize its therapeutic use after stroke. We outline recent findings from rodent models of cortical stroke of how experiences interact with post-injury events to influence synaptic connectivity and functional outcome, with a focus on upper extremity function. After unilateral cortical infarcts, behavioral experiences shape neuronal structure and activity in both hemispheres. Experiences that matter include interventions, such as skill training and constraint-like therapy, as well as unguided behaviors, such as learned nonuse and behavioral compensation. Lateralized behaviors have bihemispheric influences. Ischemic injury can alter the sensitivity of remaining neocortical neurons to behavioral change and this can have positive and negative functional effects. Because experience is ongoing in stroke survivors, a better understanding of its interaction with brain reorganization is needed so that it can be manipulated to improve function and prevent its worsening.