Influence of antidiuretic hormone on peritoneal membrane area and permeability.
Influence of antidiuretic hormone on peritoneal membrane area and permeability.
复制标题
抗利尿激素对腹膜面积和通透性的影响。
DOI：
10.1172/jci106742
复制
发表时间：
1971
期刊：
影响因子：
--
通讯作者：
J. Kintzel
中科院分区：
文献类型：
--
作者：
L. Henderson;J. Kintzel
本研究是为了确定抗利尿激素（ADH）是否改变了腹膜的溶质处理特性。用尿素-(14)C （60 mol wt）和菊粉（5200 mol wt）轻度麻醉的狗，用低渗盐水溶液扩大体积，通过尿/血浆渗透压评估抑制内源性ADH。抑制ADH后，进行2 - 3次对照腹膜透析交换。开始在生理盐水中以150 mU/hr的生理剂量持续输注ADH，并跟踪尿/血浆渗透压，直到其显著大于1。然后进行两到三次实验性透析交换。通过腹膜计算菊粉（D(I)）和尿素（D(U)）的透析量。在16项这样的研究中，D(U)除3项外均下降（下降的平均值为2.8 +/-2.6 ml/min; P < 0.001）。D(I)随机变化，无显著变化。在所有16项研究中，D(I)/D(U)上升(D(I)/D(U) = 0.054 +/- 0.054；P < 0.005)。7只狗用相同的方案进行了研究，但注入了不含ADH的生理盐水。D(U)和透析比随机变化。D(U)在1个月内下降，4个月内没有变化或上升，D(I)/D(U)在2个月内上升，3个月内下降。这些数据被解释为“腹膜”的面积下降，但平均孔半径增加，这是对静脉注射ADH生理性量的反应。面积的下降与内脏血流的减少是一致的。
The present study was carried out to determine if antidiuretic hormone (ADH) altered the solute handling characteristics of the peritoneal membrane. Lightly anesthetized dogs primed with urea-(14)C (60 mol wt) and inulin (5200 mol wt) were volume expanded with hypotonic saline solution to suppress endogenous ADH as assessed by urine/plasma osmolality. With ADH suppressed, two to three control peritoneal dialysis exchanges were carried out. A constant infusion of ADH in a physiologic dose of 150 mU/hr in saline was begun and the urine/plasma osmolality followed until it was significantly greater than one. Two to three experimental dialysis exchanges were then carried out. Dialysance across the peritoneal membrane was calculated for inulin (D(I)) and urea (D(U)). In 16 such studies D(U) fell in all but three (the mean value for the fall was 2.8 +/-2.6 ml/min; P < 0.001). D(I) varied randomly and showed no significant change. In all 16 studies D(I)/D(U) rose (D(I)/D(U) = 0.054 +/- 0.054; P < 0.005). Seven dogs were studied with an identical protocol but saline was infused without ADH. D(U) and the dialysance ratio varied randomly. D(U) fell in one and did not change or rose in four and D(I)/D(U) rose in two and fell in three. The data are interpreted to show a fall in area but an increase in mean pore radius of the "peritoneal membrane" in response to physiologic amounts of intravenous ADH. The fall in area is consistent with a decreasing splanchnic blood flow.