The measurement and therapeutic implications of circulating tumour cells in breast cancer.

The measurement and therapeutic implications of circulating tumour cells in breast cancer.
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DOI:
10.1038/sj.bjc.6602871
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发表时间:
2006-01-16
影响因子:
8.8
通讯作者:
--
中科院分区:
医学1区
文献类型:
--
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循环肿瘤细胞(CTC)代表了乳腺癌从原发性疾病向转移性疾病扩散的重要生物学联系。 CTC 是转移性乳腺癌患者预后的有力预测因子。迄今为止的研究重点是开发具有足够敏感性和特异性的方法,以可重复地识别这些罕见事件。未来的研究将集中在这些细胞的生物学表型上,目标是了解转移机制、确定新的治疗靶点并监测对治疗的反应。
Circulating tumours cells (CTCs) represent an important biologic link in the spread of breast cancer from primary to metastatic disease. CTCs are strong predictors of prognosis in patients with metastatic breast cancer. Research to date has focused on development of methods with adequate sensitivity and specificity to reproducibly identify these rare events. Future research will focus on the biologic phenotypes of these cells with goals to understand mechanisms of metastasis, to identify novel therapeutic targets, and to monitor response to therapy.
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