Distribution of Inflammation Within Carotid Atherosclerotic Plaques With High-Risk Morphological Features A Comparison Between Positron Emission Tomography Activity, Plaque Morphology, and Histopathology
Distribution of Inflammation Within Carotid Atherosclerotic Plaques With High-Risk Morphological Features A Comparison Between Positron Emission Tomography Activity, Plaque Morphology, and Histopathology
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DOI：
10.1161/circimaging.110.959478
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发表时间：
2012-01-01
影响因子：
7.5
通讯作者：
Tawakol, Ahmed
中科院分区：
文献类型：
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作者：
Figueroa, Amparo L.;Subramanian, Sharath S.;Tawakol, Ahmed
背景-斑块的几个高危形态特征(HRM)，特别是合并斑块，与临床事件的风险增加相关。虽然斑块炎症也与动脉粥样硬化血栓形成有关，但炎症与HRM数量之间的关系尚不清楚。方法和结果：34例患者接受了(18)氟脱氧葡萄糖正电子发射断层扫描(FDG-PET)成像，并评估了颈动脉粥样硬化性炎症(靶/背景比)。此外，在接受颈动脉内膜切除术的10名颈动脉狭窄患者中，对炎症进行了组织学评估(CD68染色)。使用计算机断层扫描检查血管壁形态是否存在可见的斑块和3种HRM：阳性重塑、管腔不规则和低密度。共分析了100个血管节段，其中69个包含可见斑块(26个斑块，~gt；=1个HRM)。根据摄取FDG(靶与背景的比率)，炎症反应在有(无)HRM的斑块中更高(平均+/-扫描电子显微镜：2.21+/-0.20vs1.66+/-0.07，P=0.0003)，并随着观察到的HRM的数目而增加(P
Background-Several high-risk morphological features (HRM) of plaques, especially in combination, are associated with an increased risk of a clinical event. Although plaque inflammation is also associated with atherothrombosis, the relationship between inflammation and number of HRM is not well understood.Methods and Results-Thirty-four patients underwent (18)flurodeoxyglucose positron emission tomography (FDG-PET) imaging, and carotid atherosclerotic inflammation was assessed (target-to-background ratio). Additionally, in a subset of 10 subjects with carotid stenosis who underwent carotid endarterectomy, inflammation was histologically assessed (CD68 staining). Vessel wall morphology was examined using computed tomography for the presence of visible plaque and presence of 3 HRM: positive remodeling, luminal irregularity, and low attenuation. A total of 100 vascular segments were analyzed, of which 69 contained visible plaque (26 plaques with >= 1 HRM). Inflammation, by FDG uptake (target-to-background ratio), was higher in plaques with (versus without) HRM (mean +/- SEM: 2.21 +/- 0.20 versus 1.66 +/- 0.07, P=0.0003) and increased with the number of HRM observed (P