Low-resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: Initial results from fiber-optic high-resolution manometry studies
Low-resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: Initial results from fiber-optic high-resolution manometry studies
复制标题
DOI：
10.1111/nmo.12170
复制
发表时间：
2013-10-01
影响因子：
3.5
通讯作者：
Arkwright, J. W.
中科院分区：
文献类型：
--
作者：
Dinning, P. G.;Wiklendt, L.;Arkwright, J. W.
背景高分辨率测压导管现在被用来记录结肠蠕动。本研究的目的是确定压力传感器间距对我们识别结肠传播序列 (PS) 的能力的影响。方法将包含 72-90 个传感器（间隔 1 厘米）的光纤导管通过结肠镜放置到 11 名已证实的慢传输型便秘患者、11 名神经源性大便失禁患者和 9 名健康受试者的盲肠中。分析每个受试者 2 小时的轨迹部分。使用 1 厘米间距的数据作为黄金标准，然后通过从数据集中删除通道来模拟 10、7、5、3 和 2 厘米的传感器间距，对每个数据集进行二次采样。以盲法方式，在每个测试传感器间距处对顺行和逆行 PS 进行量化。将数据与相应金标准数据集中确定的 PS 进行比较。 主要结果 在所有受试者组中，随着传感器间距的增加； (i) 已识别的顺行和逆行 PS 的频率降低（P
BackgroundHigh-resolution manometry catheters are now being used to record colonic motility. The aim of this study was to determine the influence of pressure sensor spacing on our ability to identify colonic propagating sequences (PS).MethodsFiber-optic catheters containing 72-90 sensors spaced at 1cm intervals were placed colonoscopically to the cecum in 11 patients with proven slow transit constipation, 11 patients with neurogenic fecal incontinence and nine healthy subjects. A 2h section of trace from each subject was analyzed. Using the 1cm spaced data as the gold standard, each data set was then sub-sampled, by dropping channels from the data set to simulate sensor spacing of 10, 7, 5, 3, and 2cm. In blinded fashion, antegrade and retrograde PS were quantified at each test sensor spacing. The data were compared to the PSs identified in the corresponding gold standard data set.Key ResultsIn all subject groups as sensor spacing increased; (i) the frequency of identified antegrade and retrograde PSs decreased (P