Genotypic selection provides experimental confirmation for an alcohol consumption quantitative trait locus in mouse.
Genotypic selection provides experimental confirmation for an alcohol consumption quantitative trait locus in mouse.
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基因型选择为小鼠饮酒数量性状基因座提供了实验确认。
DOI：
10.1038/sj.mp.4000320
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Plomin,R
中科院分区：
文献类型：
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作者：
McClearn,GE;Tarantino,LM;Rodriguez,LA;Jones,BC;Blizard,DA;Plomin,R
对于F2，使用GE McClearn 1，2，3，LM Tarantino 1，3，Mapmaker/QTL进行区间作图。图1a显示了LA Rodriguez 1，4、BC Jones 1，2、DA Blizard 1染色体15的结果。对于具有最佳拟合显性模型的组合性别，峰值lod评分为3.8，R Plomin 1，5约为30 cM，1 lod支持1发育与健康遗传学中心;间隔从15延伸到48 cM。实质性的性别2生物行为健康系; 3校际差异也显示出来。仅在男性中，宾夕法尼亚州遗传学研究生课程的额外峰值lod评分出现在约University，大学公园，宾夕法尼亚州16802; 5研究所17 cM，尽管证据仍然显著的精神病学，丹麦希尔，伦敦SE 5 8AF，英国（lod 3.0）在30 cM区域，但相对于性别合并数据，明显降低。雄性F2 AA中约6%的表型方差
For the F2, interval mapping was performed using GE McClearn1, 2, 3, LM Tarantino1, 3, Mapmaker/QTL. 15, 16 Figure 1a presents the results for LA Rodriguez1, 4, BC Jones1, 2, DA Blizard1 chromosome 15. For combined sexes with the best-fitting dominant model, the peak lod score of 3.8 occurs and R Plomin1, 5 at approximately 30cM, with the one-lod support 1Center for Developmental and Health Genetics; interval extending from 15 to 48 cM. Substantial sex 2Department of Biobehavioral Health; 3Intercollege differences are also shown. In males only, an Graduate Program in Genetics, The Pennsylvania State additional peak lod score occurs at approximately University, University Park, Pennsylvania 16802; 5Institute 17 cM, and, although the evidence remains significant of Psychiatry, Denmark Hill, London SE5 8AF, UK(lod 3.0) in the region of 30 cM, it is clearly reduced relative to that from the sex-combined data. Approximately 6% of the phenotypic variance in male F2 AA