Effects of acute stanozolol treatment on puberty in female rats.
Effects of acute stanozolol treatment on puberty in female rats.
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康力龙急性治疗对雌性大鼠青春期的影响。
DOI：
10.1095/biolreprod64.5.1460
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发表时间：
2001
影响因子：
3.6
通讯作者：
Clark,AS
中科院分区：
文献类型：
--
作者：
Whitney,AC;Clark,AS
合成代谢雄激素类固醇（AAS）滥用对女性青少年青春期开始的影响在很大程度上尚不清楚。本研究评估了一种 AAS（康力龙）对雌性大鼠青春期开始的急性影响。产后第 21 天（PN）单次注射康力龙（5 mg/kg）可提前阴道开口，但不会改变阴道动情的开始。较高剂量的康力龙治疗（10 和 25 mg/kg）也能促进阴道张开，但对阴道动情没有影响。在 PN20-22 上同时服用纯抗雌激素 ICI 182,780 (1 mg/kg) 可阻止康力龙 (5 mg/kg) 促进阴道张开。在 PN20-22 上给予雄激素受体拮抗剂氟他胺（10 mg/kg，每天两次）对康力龙阴道开口的进展没有影响。康力龙治疗还可以促进卵巢切除大鼠的阴道张开。在 PN21 和 PN23 上阴道周围注射低剂量康力龙（0.05 mg）也能促进阴道张开。这些结果表明，康力龙直接作用于阴道上皮中的雌激素受体，以促进阴道张开，并且青春期前康力龙治疗不会诱导真正的性早熟。
The effects of anabolic-androgenic steroid (AAS) abuse on the onset of puberty in female adolescents are largely unknown. This study assessed the acute effects of one AAS, stanozolol, on pubertal onset in the female rat. A single injection of stanozolol (5 mg/kg) on Postnatal Day (PN) 21 advanced vaginal opening but did not alter the onset of vaginal estrus. Higher doses of stanozolol treatment (10 and 25 mg/kg) also advanced vaginal opening but had no effect on vaginal estrus. The advancement of vaginal opening by stanozolol (5 mg/kg) was prevented by the concomitant administration of the pure antiestrogen ICI 182,780 (1 mg/kg) on PN20–22. Administration of the androgen receptor antagonist flutamide (10 mg/kg twice daily) on PN20–22 had no effect on the advancement of vaginal opening by stanozolol. Stanozolol treatment also advanced vaginal opening in ovariectomized rats. Perivaginal injections of a low dose of stanozolol (0.05 mg) on PN21 and PN23 also advanced vaginal opening. These results suggest that stanozolol is acting directly at estrogen receptors in the vaginal epithelium to advance vaginal opening and that prepubertal stanozolol treatment does not induce true precocious puberty.