Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides
Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides
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Cu(II) 催化炔酸酯与硫代酰胺的加成/氧化环化直接合成多取代 2-氨基噻吩
DOI：
10.1039/c4ob01534g
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发表时间：
2014-11-14
影响因子：
3.2
通讯作者：
Deng, Wei-Ping
中科院分区：
文献类型：
--
作者：
Ge, Li-Shi;Wang, Zheng-Lin;Deng, Wei-Ping
开发了一种简便和直接的合成方法，用于以中等至优异的产率（高达91%）构建结构上重要的2-氨基噻吩，通过Cu（II）催化的加成/氧化环化容易获得的硫代酰胺与炔酸酯在空气气氛下。
A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(II)-catalyzed addition/oxidative cyclization of readily available thioamides with alkynoates under an air atmosphere.